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Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer’s Disease
Yi-Chen Hsieh, Caiwei Guo, Hari K. Yalamanchili, Measho Abreha, Rami Al-Ouran, Yarong Li, Eric B. Dammer, James J. Lah, Allan I. Levey, David A. Bennett, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman
doi: https://doi.org/10.1101/514927
Yi-Chen Hsieh
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Caiwei Guo
2Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Hari K. Yalamanchili
3Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Measho Abreha
4Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
Rami Al-Ouran
3Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Yarong Li
5Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
Eric B. Dammer
4Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
James J. Lah
6Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Allan I. Levey
6Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
David A. Bennett
7Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA
Philip L. De Jager
8Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
9Cell Circuits Program, Broad Institute, Cambridge, MA 02142, USA
Nicholas T. Seyfried
4Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
6Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Zhandong Liu
3Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
10Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
Joshua M. Shulman
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
2Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
5Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
10Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
Article usage
Posted January 09, 2019.
Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer’s Disease
Yi-Chen Hsieh, Caiwei Guo, Hari K. Yalamanchili, Measho Abreha, Rami Al-Ouran, Yarong Li, Eric B. Dammer, James J. Lah, Allan I. Levey, David A. Bennett, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman
bioRxiv 514927; doi: https://doi.org/10.1101/514927
Tau-mediated Disruption of the Spliceosome Triggers Cryptic RNA-splicing and Neurodegeneration in Alzheimer’s Disease
Yi-Chen Hsieh, Caiwei Guo, Hari K. Yalamanchili, Measho Abreha, Rami Al-Ouran, Yarong Li, Eric B. Dammer, James J. Lah, Allan I. Levey, David A. Bennett, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu, Joshua M. Shulman
bioRxiv 514927; doi: https://doi.org/10.1101/514927
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