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Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning
Eric M. Jones, View ORCID ProfileNathan B. Lubock, View ORCID ProfileAJ Venkatakrishnan, Jeffrey Wang, Alex M. Tseng, View ORCID ProfileJoseph M. Paggi, View ORCID ProfileNaomi R. Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E. Davis, View ORCID ProfileM. Madan Babu, View ORCID ProfileRon O. Dror, View ORCID ProfileSriram Kosuri
doi: https://doi.org/10.1101/623108
Eric M. Jones
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
Nathan B. Lubock
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
AJ Venkatakrishnan
2MRC Laboratory of Molecular Biology, Francis Crick Ave, Cambridge CB2 0QH, UK
3Department of Computer Science, Stanford University, Stanford, CA 94305, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Jeffrey Wang
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
Alex M. Tseng
3Department of Computer Science, Stanford University, Stanford, CA 94305, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Joseph M. Paggi
3Department of Computer Science, Stanford University, Stanford, CA 94305, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Naomi R. Latorraca
3Department of Computer Science, Stanford University, Stanford, CA 94305, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Daniel Cancilla
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
Megan Satyadi
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
Jessica E. Davis
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
M. Madan Babu
2MRC Laboratory of Molecular Biology, Francis Crick Ave, Cambridge CB2 0QH, UK
Ron O. Dror
3Department of Computer Science, Stanford University, Stanford, CA 94305, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Sriram Kosuri
1Department of Chemistry and Biochemistry, UCLA-DOE Institute for Genomics and Proteomics, Molecular Biology Institute, Quantitative and Computational Biology Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA
Posted May 10, 2019.
Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning
Eric M. Jones, Nathan B. Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M. Tseng, Joseph M. Paggi, Naomi R. Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E. Davis, M. Madan Babu, Ron O. Dror, Sriram Kosuri
bioRxiv 623108; doi: https://doi.org/10.1101/623108
Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning
Eric M. Jones, Nathan B. Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M. Tseng, Joseph M. Paggi, Naomi R. Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E. Davis, M. Madan Babu, Ron O. Dror, Sriram Kosuri
bioRxiv 623108; doi: https://doi.org/10.1101/623108
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