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Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
View ORCID ProfileRogan A. Grant, View ORCID ProfileLuisa Morales-Nebreda, View ORCID ProfileNikolay S. Markov, View ORCID ProfileSuchitra Swaminathan, View ORCID ProfileEstefany R. Guzman, View ORCID ProfileDarryl A. Abbott, View ORCID ProfileHelen K. Donnelly, View ORCID ProfileAlvaro Donayre, View ORCID ProfileIsaac A. Goldberg, View ORCID ProfileZasu M. Klug, View ORCID ProfileNicole Borkowski, View ORCID ProfileZiyan Lu, View ORCID ProfileHermon Kihshen, View ORCID ProfileYuliya Politanska, View ORCID ProfileLango Sichizya, View ORCID ProfileMengjia Kang, View ORCID ProfileAli Shilatifard, View ORCID ProfileChao Qi, View ORCID ProfileA. Christine Argento, View ORCID ProfileJacqueline M. Kruser, View ORCID ProfileElizabeth S. Malsin, View ORCID ProfileChiagozie O. Pickens, View ORCID ProfileSean Smith, View ORCID ProfileJames M. Walter, View ORCID ProfileAnna E. Pawlowski, View ORCID ProfileDaniel Schneider, View ORCID ProfilePrasanth Nannapaneni, View ORCID ProfileHiam Abdala-Valencia, View ORCID ProfileAnkit Bharat, View ORCID ProfileCara J. Gottardi, View ORCID ProfileGR Scott Budinger, View ORCID ProfileAlexander V. Misharin, View ORCID ProfileBenjamin D. Singer, View ORCID ProfileRichard G. Wunderink, for The NU SCRIPT Study Investigators
doi: https://doi.org/10.1101/2020.08.05.238188
Rogan A. Grant
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Luisa Morales-Nebreda
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Nikolay S. Markov
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Suchitra Swaminathan
2Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University
3Robert H Lurie Comprehensive Cancer Research Center, Feinberg School of Medicine, Northwestern University
Estefany R. Guzman
3Robert H Lurie Comprehensive Cancer Research Center, Feinberg School of Medicine, Northwestern University
Darryl A. Abbott
3Robert H Lurie Comprehensive Cancer Research Center, Feinberg School of Medicine, Northwestern University
Helen K. Donnelly
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Alvaro Donayre
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Isaac A. Goldberg
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Zasu M. Klug
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Nicole Borkowski
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Ziyan Lu
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Hermon Kihshen
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Yuliya Politanska
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Lango Sichizya
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Mengjia Kang
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Ali Shilatifard
4Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
5Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University
Chao Qi
6Department of Pathology, Feinberg School of Medicine, Northwestern University
A. Christine Argento
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Jacqueline M. Kruser
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Elizabeth S. Malsin
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Chiagozie O. Pickens
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Sean Smith
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
James M. Walter
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Anna E. Pawlowski
7Clinical and Translational Sciences Institute, Feinberg School of Medicine, Northwestern University
Daniel Schneider
7Clinical and Translational Sciences Institute, Feinberg School of Medicine, Northwestern University
Prasanth Nannapaneni
7Clinical and Translational Sciences Institute, Feinberg School of Medicine, Northwestern University
Hiam Abdala-Valencia
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Ankit Bharat
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
8Division of Thoracic Surgery, Department of Surgery, Feinberg School of Medicine, Northwestern University
Cara J. Gottardi
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
GR Scott Budinger
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Alexander V. Misharin
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
Benjamin D. Singer
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
4Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
5Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University
Richard G. Wunderink
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University
5Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University
Posted August 05, 2020.
Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
Rogan A. Grant, Luisa Morales-Nebreda, Nikolay S. Markov, Suchitra Swaminathan, Estefany R. Guzman, Darryl A. Abbott, Helen K. Donnelly, Alvaro Donayre, Isaac A. Goldberg, Zasu M. Klug, Nicole Borkowski, Ziyan Lu, Hermon Kihshen, Yuliya Politanska, Lango Sichizya, Mengjia Kang, Ali Shilatifard, Chao Qi, A. Christine Argento, Jacqueline M. Kruser, Elizabeth S. Malsin, Chiagozie O. Pickens, Sean Smith, James M. Walter, Anna E. Pawlowski, Daniel Schneider, Prasanth Nannapaneni, Hiam Abdala-Valencia, Ankit Bharat, Cara J. Gottardi, GR Scott Budinger, Alexander V. Misharin, Benjamin D. Singer, Richard G. Wunderink, for The NU SCRIPT Study Investigators
bioRxiv 2020.08.05.238188; doi: https://doi.org/10.1101/2020.08.05.238188
Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells
Rogan A. Grant, Luisa Morales-Nebreda, Nikolay S. Markov, Suchitra Swaminathan, Estefany R. Guzman, Darryl A. Abbott, Helen K. Donnelly, Alvaro Donayre, Isaac A. Goldberg, Zasu M. Klug, Nicole Borkowski, Ziyan Lu, Hermon Kihshen, Yuliya Politanska, Lango Sichizya, Mengjia Kang, Ali Shilatifard, Chao Qi, A. Christine Argento, Jacqueline M. Kruser, Elizabeth S. Malsin, Chiagozie O. Pickens, Sean Smith, James M. Walter, Anna E. Pawlowski, Daniel Schneider, Prasanth Nannapaneni, Hiam Abdala-Valencia, Ankit Bharat, Cara J. Gottardi, GR Scott Budinger, Alexander V. Misharin, Benjamin D. Singer, Richard G. Wunderink, for The NU SCRIPT Study Investigators
bioRxiv 2020.08.05.238188; doi: https://doi.org/10.1101/2020.08.05.238188
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