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Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
View ORCID ProfileBruna Paulsen, View ORCID ProfileSilvia Velasco, View ORCID ProfileAmanda J. Kedaigle, View ORCID ProfileMartina Pigoni, Giorgia Quadrato, Anthony Deo, Xian Adiconis, Ana Uzquiano, Kwanho Kim, Sean K. Simmons, Kalliopi Tsafou, Alex Albanese, Rafaela Sartore, Catherine Abbate, Ashley Tucewicz, Samantha Smith, Kwanghun Chung, Kasper Lage, View ORCID ProfileAviv Regev, View ORCID ProfileJoshua Z. Levin, Paola Arlotta
doi: https://doi.org/10.1101/2020.11.10.376509
Bruna Paulsen
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Silvia Velasco
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Amanda J. Kedaigle
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Martina Pigoni
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Giorgia Quadrato
4Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;
5Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Los Angeles, CA 90033, USA.
Anthony Deo
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
6Department of Psychiatry, Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA
7Department of Psychiatry, Rutgers-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854
8University Behavioral Healthcare, 671 Hoes Lane West, Piscataway, NJ 08854
Xian Adiconis
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Ana Uzquiano
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Kwanho Kim
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Sean K. Simmons
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Kalliopi Tsafou
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Alex Albanese
9Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA
Rafaela Sartore
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Catherine Abbate
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Ashley Tucewicz
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Samantha Smith
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Kwanghun Chung
9Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA
10Picower Institute for Learning and Memory, MIT, Cambridge, MA 02139, USA
11Department of Chemical Engineering, MIT, Cambridge, MA 02142, USA
12Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
Kasper Lage
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
13Department of Surgery and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
Aviv Regev
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
14Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Joshua Z. Levin
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
3Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Paola Arlotta
1Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
2Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
Posted November 12, 2020.
Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
Bruna Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, Anthony Deo, Xian Adiconis, Ana Uzquiano, Kwanho Kim, Sean K. Simmons, Kalliopi Tsafou, Alex Albanese, Rafaela Sartore, Catherine Abbate, Ashley Tucewicz, Samantha Smith, Kwanghun Chung, Kasper Lage, Aviv Regev, Joshua Z. Levin, Paola Arlotta
bioRxiv 2020.11.10.376509; doi: https://doi.org/10.1101/2020.11.10.376509
Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
Bruna Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, Anthony Deo, Xian Adiconis, Ana Uzquiano, Kwanho Kim, Sean K. Simmons, Kalliopi Tsafou, Alex Albanese, Rafaela Sartore, Catherine Abbate, Ashley Tucewicz, Samantha Smith, Kwanghun Chung, Kasper Lage, Aviv Regev, Joshua Z. Levin, Paola Arlotta
bioRxiv 2020.11.10.376509; doi: https://doi.org/10.1101/2020.11.10.376509
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