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Phospho-IWS1-dependent U2AF2 splicing is cell-cycle-regulated, promotes proliferation and predicts poor prognosis of EGFR-mutant lung adenocarcinoma
View ORCID ProfileGeorgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul D. Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Salvatore Alaimo, Arturo Orlacchio, Keith A. Nair II, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, View ORCID ProfileLalit Sehgal, David P. Carbone, View ORCID ProfileVincenzo Coppola, Philip N. Tsichlis
doi: https://doi.org/10.1101/2020.07.14.195297
Georgios I. Laliotis
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
3University of Crete, School of Medicine, Heraklion Crete, 71500, Greece
4Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA
Evangelia Chavdoula
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Maria D. Paraskevopoulou
5Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA, 02111, USA
6Takeda Pharmaceuticals U.S.A, Boston, MA, 02139, USA
Abdul D. Kaba
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Alessandro La Ferlita
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
7Department of Clinical and Experimental Medicine, Bioinformatics Unit, University of Catania, Catania, 95131, Italy
Satishkumar Singh
8College of Medicine, Department of Hematology, The Ohio State University, Columbus, OH 43210
Vollter Anastas
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
9Tufts Graduate School of Biomedical Sciences, Program in Genetics, Boston, MA, 02111, USA
Salvatore Alaimo
7Department of Clinical and Experimental Medicine, Bioinformatics Unit, University of Catania, Catania, 95131, Italy
Arturo Orlacchio
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Keith A. Nair II
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Vasiliki Taraslia
4Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA
10Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527, Greece
Ioannis Vlachos
11DIANA-Lab, Hellenic Pasteur Institute, Athens, 11521, Greece
12Beth Israel-Deaconess Medical Center, Department Of Pathology, Harvard Medical School, Boston, MA 02215, USA
Marina Capece
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Artemis Hatzigeorgiou
11DIANA-Lab, Hellenic Pasteur Institute, Athens, 11521, Greece
Dario Palmieri
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Christos Tsatsanis
13Department of Clinical Chemistry-Biochemistry, School of Medicine, University of Crete, Heraklion 71110, Crete, Greece
14Institute for Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion 70013, Greece
Lalit Sehgal
6Takeda Pharmaceuticals U.S.A, Boston, MA, 02139, USA
David P. Carbone
15Department of Internal Medicine, Division of Medical Oncology, The Ohio State University Medical Center, Columbus, OH, 43210, USA
Vincenzo Coppola
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Philip N. Tsichlis
1The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, 43210, USA
2The Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, 43210, USA
Posted March 10, 2021.
Phospho-IWS1-dependent U2AF2 splicing is cell-cycle-regulated, promotes proliferation and predicts poor prognosis of EGFR-mutant lung adenocarcinoma
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul D. Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Salvatore Alaimo, Arturo Orlacchio, Keith A. Nair II, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
bioRxiv 2020.07.14.195297; doi: https://doi.org/10.1101/2020.07.14.195297
Phospho-IWS1-dependent U2AF2 splicing is cell-cycle-regulated, promotes proliferation and predicts poor prognosis of EGFR-mutant lung adenocarcinoma
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul D. Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Salvatore Alaimo, Arturo Orlacchio, Keith A. Nair II, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis
bioRxiv 2020.07.14.195297; doi: https://doi.org/10.1101/2020.07.14.195297
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