New Results
Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain
Pengfei Dong, View ORCID ProfileGabriel E. Hoffman, Pasha Apontes, Jaroslav Bendl, Samir Rahman, Michael B. Fernando, Biao Zeng, James M. Vicari, Wen Zhang, Kiran Girdhar, Kayla G. Townsley, Ruth Misir, the CommonMind Consortium, Kristen J. Brennand, Vahram Haroutunian, View ORCID ProfileGeorgios Voloudakis, John F. Fullard, Panos Roussos
doi: https://doi.org/10.1101/2021.05.14.443421
Pengfei Dong
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Gabriel E. Hoffman
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Pasha Apontes
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
9Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, 10468, USA
Jaroslav Bendl
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Samir Rahman
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Michael B. Fernando
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Department of Neuroscience Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
7Black Family Stem Cell Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Biao Zeng
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
James M. Vicari
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Wen Zhang
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Kiran Girdhar
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Kayla G. Townsley
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Department of Neuroscience Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Ruth Misir
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Kristen J. Brennand
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Department of Neuroscience Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
7Black Family Stem Cell Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
10Department of Psychiatry, Yale University, New Haven, CT 06511, USA
Vahram Haroutunian
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
6Department of Neuroscience Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
9Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, 10468, USA
Georgios Voloudakis
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
John F. Fullard
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Panos Roussos
1Pamela Sklar Division of Psychiatric Genomics Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2Friedman Brain Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
3Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
4Department of Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
5Department of Genetics and Genomic Science Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
8Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
9Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, 10468, USA
Posted June 11, 2021.
Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain
Pengfei Dong, Gabriel E. Hoffman, Pasha Apontes, Jaroslav Bendl, Samir Rahman, Michael B. Fernando, Biao Zeng, James M. Vicari, Wen Zhang, Kiran Girdhar, Kayla G. Townsley, Ruth Misir, the CommonMind Consortium, Kristen J. Brennand, Vahram Haroutunian, Georgios Voloudakis, John F. Fullard, Panos Roussos
bioRxiv 2021.05.14.443421; doi: https://doi.org/10.1101/2021.05.14.443421
Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain
Pengfei Dong, Gabriel E. Hoffman, Pasha Apontes, Jaroslav Bendl, Samir Rahman, Michael B. Fernando, Biao Zeng, James M. Vicari, Wen Zhang, Kiran Girdhar, Kayla G. Townsley, Ruth Misir, the CommonMind Consortium, Kristen J. Brennand, Vahram Haroutunian, Georgios Voloudakis, John F. Fullard, Panos Roussos
bioRxiv 2021.05.14.443421; doi: https://doi.org/10.1101/2021.05.14.443421
Subject Area
Subject Areas
- Biochemistry (11744)
- Bioengineering (8751)
- Bioinformatics (29193)
- Biophysics (14968)
- Cancer Biology (12094)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18303)
- Genetics (12244)
- Genomics (16801)
- Immunology (11866)
- Microbiology (28082)
- Molecular Biology (11592)
- Neuroscience (60959)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10427)
- Synthetic Biology (2885)
- Systems Biology (7339)
- Zoology (1651)