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IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2
View ORCID ProfileGeorgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, View ORCID ProfileLalit Sehgal, View ORCID ProfileVincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
doi: https://doi.org/10.1101/2020.12.26.424461
Georgios I. Laliotis
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
2University of Crete, School of Medicine, Heraklion Crete, Greece, 71500
9Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205 USA
Adam D. Kenney
3Department of Microbial Infection and Immunity and Infectious Diseases Institute, The Ohio State University, Columbus, OH, 43210
Evangelia Chavdoula
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
Arturo Orlacchio
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
Abdul Kaba
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
Alessandro La Ferlita
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
4Department of Clinical and Experimental Medicine, Bioinformatics Unit, University of Catania, Catania, Italy 95131
Vollter Anastas
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
5Tufts Graduate School of Biomedical Sciences, Program in Genetics, Boston, MA, 02111
Christos Tsatsanis
2University of Crete, School of Medicine, Heraklion Crete, Greece, 71500
6Institute of Molecular Biology and Biotechnology, Heraklion, Crete, Greece 70013
Joal D. Beane
2University of Crete, School of Medicine, Heraklion Crete, Greece, 71500
7Department of Surgery, Division of Surgical Oncology, Columbus, OH 43210
Lalit Sehgal
8Department of Medicine, Division of Hematology, The Ohio State University, Columbus, OH 43210
Vincenzo Coppola
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
2University of Crete, School of Medicine, Heraklion Crete, Greece, 71500
Jacob S. Yount
3Department of Microbial Infection and Immunity and Infectious Diseases Institute, The Ohio State University, Columbus, OH, 43210
Philip N. Tsichlis
1Department of Cancer Biology and Genetics, and The Ohio State University Comprehensive Cancer Center Columbus, OH, 43210
Posted August 12, 2021.
IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
bioRxiv 2020.12.26.424461; doi: https://doi.org/10.1101/2020.12.26.424461
IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
bioRxiv 2020.12.26.424461; doi: https://doi.org/10.1101/2020.12.26.424461
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