New Results
Large-Scale Deep Multi-Layer Analysis of Alzheimer’s Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level
View ORCID ProfileErik C.B. Johnson, E. Kathleen Carter, View ORCID ProfileEric B. Dammer, Duc M. Duong, Ekaterina S. Gerasimov, Yue Liu, Jiaqi Liu, Ranjita Betarbet, Lingyan Ping, Luming Yin, Geidy E. Serrano, Thomas G. Beach, Junmin Peng, View ORCID ProfilePhilip L. De Jager, Vahram Haroutunian, Bin Zhang, Chris Gaiteri, David A. Bennett, Marla Gearing, View ORCID ProfileThomas S. Wingo, Aliza P. Wingo, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
doi: https://doi.org/10.1101/2021.04.05.438450
Erik C.B. Johnson
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
E. Kathleen Carter
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Eric B. Dammer
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Duc M. Duong
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Ekaterina S. Gerasimov
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Yue Liu
4Department of Genetics, Emory University School of Medicine, Atlanta, GA, USA
Jiaqi Liu
4Department of Genetics, Emory University School of Medicine, Atlanta, GA, USA
Ranjita Betarbet
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Lingyan Ping
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Luming Yin
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Geidy E. Serrano
7Banner Sun Health Research Institute, Sun City, AZ, USA
Thomas G. Beach
7Banner Sun Health Research Institute, Sun City, AZ, USA
Junmin Peng
8Departments of Structural Biology and Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA
9Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital, Memphis, TN, USA
Philip L. De Jager
10Center for Translational & Computational Neuroimmunology, Department of Neurology, Taub Institute, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY, USA
Vahram Haroutunian
11Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
12JJ Peters VA Medical Center MIRECC, 130 West Kingsbridge Road, Bronx, NY, USA
Bin Zhang
13Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA
Chris Gaiteri
14Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
David A. Bennett
14Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
Marla Gearing
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
6Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Thomas S. Wingo
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
4Department of Genetics, Emory University School of Medicine, Atlanta, GA, USA
Aliza P. Wingo
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
5Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
15Division of Mental Health, Atlanta VA Medical Center, GA, USA
James J. Lah
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Allan I. Levey
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Nicholas T. Seyfried
1Goizueta Alzheimer’s Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA
2Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
3Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
Posted August 13, 2021.
Large-Scale Deep Multi-Layer Analysis of Alzheimer’s Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level
Erik C.B. Johnson, E. Kathleen Carter, Eric B. Dammer, Duc M. Duong, Ekaterina S. Gerasimov, Yue Liu, Jiaqi Liu, Ranjita Betarbet, Lingyan Ping, Luming Yin, Geidy E. Serrano, Thomas G. Beach, Junmin Peng, Philip L. De Jager, Vahram Haroutunian, Bin Zhang, Chris Gaiteri, David A. Bennett, Marla Gearing, Thomas S. Wingo, Aliza P. Wingo, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
bioRxiv 2021.04.05.438450; doi: https://doi.org/10.1101/2021.04.05.438450
Large-Scale Deep Multi-Layer Analysis of Alzheimer’s Disease Brain Reveals Strong Proteomic Disease-Related Changes Not Observed at the RNA Level
Erik C.B. Johnson, E. Kathleen Carter, Eric B. Dammer, Duc M. Duong, Ekaterina S. Gerasimov, Yue Liu, Jiaqi Liu, Ranjita Betarbet, Lingyan Ping, Luming Yin, Geidy E. Serrano, Thomas G. Beach, Junmin Peng, Philip L. De Jager, Vahram Haroutunian, Bin Zhang, Chris Gaiteri, David A. Bennett, Marla Gearing, Thomas S. Wingo, Aliza P. Wingo, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
bioRxiv 2021.04.05.438450; doi: https://doi.org/10.1101/2021.04.05.438450
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