New Results
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, View ORCID ProfileAnthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, View ORCID ProfileMelissa L. Boby, Bruce Borden, View ORCID ProfileGregory R. Bowman, View ORCID ProfileJuliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Emma Cattermole, Eugene Chernyshenko, View ORCID ProfileJohn D. Chodera, Austin Clyde, View ORCID ProfileJoseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, View ORCID ProfileDavid L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, View ORCID ProfilePeter K. Eastman, Noam Erez, Charles J. Eyermann, View ORCID ProfileMike Fairhead, Gwen Fate, View ORCID ProfileDaren Fearon, Oleg Fedorov, Matteo Ferla, View ORCID ProfileRafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, View ORCID ProfileAdolfo Garcia-Sastre, View ORCID ProfileVictor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, View ORCID ProfileWilliam G. Glass, Robert Glen, Itai Glinert, View ORCID ProfileAndre S. Godoy, Marian Gorichko, View ORCID ProfileTyler Gorrie-Stone, View ORCID ProfileEd J. Griffen, Storm Hassell Hart, Jag Heer, View ORCID ProfileMichael Henry, View ORCID ProfileMichelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, View ORCID ProfileDirk Jochmans, Tobias John, View ORCID ProfileSteven De Jonghe, Anastassia L. Kantsadi, View ORCID ProfilePeter W. Kenny, View ORCID ProfileJ. L. Kiappes, View ORCID ProfileLizbe Koekemoer, Boris Kovar, View ORCID ProfileTobias Krojer, Alpha A. Lee, View ORCID ProfileBruce A. Lefker, Haim Levy, View ORCID ProfileNir London, Petra Lukacik, View ORCID ProfileHannah Bruce Macdonald, Beth MacLean, View ORCID ProfileTika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Oleg Michurin, Halina Mikolajek, View ORCID ProfileBruce F. Milne, Aaron Morris, View ORCID ProfileGarrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, View ORCID ProfileJose Brandao Neto, View ORCID ProfileJohan Neyts, Luong Nguyen, View ORCID ProfileGabriela D. Noske, View ORCID ProfileVladas Oleinikovas, View ORCID ProfileGlaucius Oliva, View ORCID ProfileGijs J. Overheul, David Owen, Vladimir Psenak, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, View ORCID ProfileAilsa Powell, Reut Puni, View ORCID ProfileVictor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, View ORCID ProfileJaime Rodriguez-Guerra, View ORCID ProfileRomel Rosales, View ORCID ProfileDominic Rufa, View ORCID ProfileChris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, View ORCID ProfileSukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, View ORCID ProfileMihaela D. Smilova, Leonardo J. Solmesky, View ORCID ProfileJohn Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, View ORCID ProfileWarren Thompson, View ORCID ProfileAndrew Thompson, Warren Thompson, Susana Tomasio, Anthony Tumber, View ORCID ProfileIoannis Vakonakis, View ORCID ProfileRonald P. van Rij, View ORCID ProfileLaura Vangeel, View ORCID ProfileFinny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, View ORCID ProfileAndrea Volkamer, View ORCID ProfileFrank von Delft, View ORCID ProfileAnnette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, View ORCID ProfileKris M. White, View ORCID ProfileConor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, View ORCID ProfileNicole Zitzmann
doi: https://doi.org/10.1101/2020.10.29.339317
1Israel Institution of Biological Research
Hagit Achdout
1Israel Institution of Biological Research
Anthony Aimon
2Diamond Light Source Ltd; Research Complex at Harwell
Elad Bar-David
1Israel Institution of Biological Research
Haim Barr
3The Weizmann Institute of Science
Amir Ben-Shmuel
1Israel Institution of Biological Research
James Bennett
4University of Oxford
Melissa L. Boby
5Memorial Sloan Kettering Cancer Center;Weil Cornell Medical College
Bruce Borden
6Folding@home Consortium
Gregory R. Bowman
7Washington University School of Medicine
Juliane Brun
4University of Oxford
Sarma BVNBS
8Sai Life Sciences
Mark Calmiano
9UCB
Anna Carbery
10University of Oxford;Diamond Light Source
Emma Cattermole
4University of Oxford
Eugene Chernyshenko
11Enamine Ltd
John D. Chodera
12Memorial Sloan Kettering Cancer Center
Austin Clyde
13Argonne National Laboratory
Joseph E. Coffland
14N/A
Galit Cohen
3The Weizmann Institute of Science
Jason Cole
15Cambridge Crystallographic Datacentre
Alessandro Contini
16University of Milan
Lisa Cox
17Life Compass Consulting Ltd
Milan Cvitkovic
18PostEra Inc.
Alex Dias
2Diamond Light Source Ltd; Research Complex at Harwell
Kim Donckers
19Katholieke Universiteit Leuven
David L. Dotson
14N/A
Alice Douangamath
2Diamond Light Source Ltd; Research Complex at Harwell
Shirly Duberstein
3The Weizmann Institute of Science
Tim Dudgeon
20Informatics Matters
Louise Dunnett
2Diamond Light Source Ltd; Research Complex at Harwell
Peter K. Eastman
21Department of Bioengineering until Sept. 1, then Department of Chemistry
Noam Erez
1Israel Institution of Biological Research
Charles J. Eyermann
22Northeastern University
Mike Fairhead
4University of Oxford
Gwen Fate
23Thames Pharma Partners
Daren Fearon
2Diamond Light Source Ltd; Research Complex at Harwell
Oleg Fedorov
4University of Oxford
Matteo Ferla
4University of Oxford
Rafaela S. Fernandes
24University of Sao Paulo
Lori Ferrins
22Northeastern University
Richard Foster
25University of Leeds
Holly Foster
25University of Leeds
Ronen Gabizon
3The Weizmann Institute of Science
Adolfo Garcia-Sastre
26Mount Sinai
Victor O. Gawriljuk
24University of Sao Paulo
Paul Gehrtz
3The Weizmann Institute of Science
Carina Gileadi
4University of Oxford
Charline Giroud
4University of Oxford
William G. Glass
12Memorial Sloan Kettering Cancer Center
Robert Glen
27University of Cambridge
Itai Glinert
1Israel Institution of Biological Research
Andre S. Godoy
24University of Sao Paulo
Marian Gorichko
28Taras Shevchenko National University of Kyiv
Tyler Gorrie-Stone
2Diamond Light Source Ltd; Research Complex at Harwell
Ed J. Griffen
29MedChemica Ltd
Storm Hassell Hart
30University of Sussex
Jag Heer
9UCB
Michael Henry
12Memorial Sloan Kettering Cancer Center
Michelle Hill
4University of Oxford
Sam Horrell
2Diamond Light Source Ltd; Research Complex at Harwell
Matthew F.D. Hurley
31Temple University
Tomer Israely
1Israel Institution of Biological Research
Andrew Jajack
18PostEra Inc.
Eric Jnoff
9UCB
Dirk Jochmans
19Katholieke Universiteit Leuven
Tobias John
4University of Oxford
Steven De Jonghe
19Katholieke Universiteit Leuven
Anastassia L. Kantsadi
4University of Oxford
Peter W. Kenny
32Universidade de Sao Paulo
J. L. Kiappes
4University of Oxford
Lizbe Koekemoer
4University of Oxford
Boris Kovar
33M2M solutions, s.r.o
Tobias Krojer
4University of Oxford
Alpha A. Lee
34PostEra Inc.; University of Cambridge
Bruce A. Lefker
35Thames Pharma Partners LLC
Haim Levy
1Israel Institution of Biological Research
Nir London
3The Weizmann Institute of Science
Petra Lukacik
2Diamond Light Source Ltd; Research Complex at Harwell
Hannah Bruce Macdonald
12Memorial Sloan Kettering Cancer Center
Beth MacLean
4University of Oxford
Tika R. Malla
4University of Oxford
Tatiana Matviiuk
11Enamine Ltd
Willam McCorkindale
27University of Cambridge
Briana L. McGovern
26Mount Sinai
Sharon Melamed
1Israel Institution of Biological Research
Oleg Michurin
11Enamine Ltd
Halina Mikolajek
2Diamond Light Source Ltd; Research Complex at Harwell
Bruce F. Milne
36University of Coimbra
Aaron Morris
37PostEra Inc
Garrett M. Morris
4University of Oxford
Melody Jane Morwitzer
38Department of Pathology and Microbiology
Demetri Moustakas
39Relay Therapeutics
Aline M. Nakamura
24University of Sao Paulo
Jose Brandao Neto
2Diamond Light Source Ltd; Research Complex at Harwell
Johan Neyts
19Katholieke Universiteit Leuven
Luong Nguyen
18PostEra Inc.
Gabriela D. Noske
24University of Sao Paulo
Vladas Oleinikovas
9UCB
Glaucius Oliva
24University of Sao Paulo
Gijs J. Overheul
40Radboud University Medical Center
David Owen
2Diamond Light Source Ltd; Research Complex at Harwell
Vladimir Psenak
33M2M solutions, s.r.o
Ruby Pai
18PostEra Inc.
Jin Pan
18PostEra Inc.
Nir Paran
1Israel Institution of Biological Research
Benjamin Perry
41DNDi
Maneesh Pingle
8Sai Life Sciences
Jakir Pinjari
8Sai Life Sciences
Boaz Politi
1Israel Institution of Biological Research
Ailsa Powell
2Diamond Light Source Ltd; Research Complex at Harwell
Reut Puni
1Israel Institution of Biological Research
Victor L. Rangel
42School of Pharmaceutical Sciences of Ribeirao Preto
Rambabu N. Reddi
3The Weizmann Institute of Science
St Patrick Reid
38Department of Pathology and Microbiology
Efrat Resnick
3The Weizmann Institute of Science
Emily Grace Ripka
18PostEra Inc.
Matthew C. Robinson
18PostEra Inc.
Ralph P. Robinson
35Thames Pharma Partners LLC
Jaime Rodriguez-Guerra
43Charite Universitatsmedizin Berlin
Romel Rosales
26Mount Sinai
Dominic Rufa
12Memorial Sloan Kettering Cancer Center
Chris Schofield
4University of Oxford
Mikhail Shafeev
11Enamine Ltd
Aarif Shaikh
8Sai Life Sciences
Jiye Shi
9UCB
Khriesto Shurrush
3The Weizmann Institute of Science
Sukrit Singh
12Memorial Sloan Kettering Cancer Center
Assa Sittner
1Israel Institution of Biological Research
Rachael Skyner
2Diamond Light Source Ltd; Research Complex at Harwell
Adam Smalley
9UCB
Mihaela D. Smilova
4University of Oxford
Leonardo J. Solmesky
3The Weizmann Institute of Science
John Spencer
30University of Sussex
Claire Strain-Damerell
2Diamond Light Source Ltd; Research Complex at Harwell
Vishwanath Swamy
8Sai Life Sciences
Hadas Tamir
1Israel Institution of Biological Research
Rachael Tennant
44Lhasa Ltd. UK
Warren Thompson
2Diamond Light Source Ltd; Research Complex at Harwell
Andrew Thompson
4University of Oxford
Warren Thompson
2Diamond Light Source Ltd; Research Complex at Harwell
Susana Tomasio
45Collaborative Drug Discovery
Anthony Tumber
4University of Oxford
Ioannis Vakonakis
4University of Oxford
Ronald P. van Rij
40Radboud University Medical Center
Laura Vangeel
19Katholieke Universiteit Leuven
Finny S. Varghese
40Radboud University Medical Center
Mariana Vaschetto
45Collaborative Drug Discovery
Einat B. Vitner
1Israel Institution of Biological Research
Vincent Voelz
31Temple University
Andrea Volkamer
43Charite Universitatsmedizin Berlin
Frank von Delft
46Diamond Light Source Ltd; University of Oxford; Research Complex at Harwell; University of Johannesburg
Annette von Delft
4University of Oxford
Martin Walsh
2Diamond Light Source Ltd; Research Complex at Harwell
Walter Ward
47Walter Ward Consultancy & Training
Charlie Weatherall
45Collaborative Drug Discovery
Shay Weiss
1Israel Institution of Biological Research
Kris M. White
26Mount Sinai
Conor Francis Wild
4University of Oxford
Matthew Wittmann
12Memorial Sloan Kettering Cancer Center
Nathan Wright
4University of Oxford
Yfat Yahalom-Ronen
1Israel Institution of Biological Research
Daniel Zaidmann
3The Weizmann Institute of Science
Hadeer Zidane
3The Weizmann Institute of Science
Nicole Zitzmann
4University of Oxford
Posted October 18, 2021.
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Emma Cattermole, Eugene Chernyshenko, John D. Chodera, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Fedorov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, Itai Glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J. L. Kiappes, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha A. Lee, Bruce A. Lefker, Haim Levy, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J. Overheul, David Owen, Vladimir Psenak, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Reut Puni, Victor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Warren Thompson, Susana Tomasio, Anthony Tumber, Ioannis Vakonakis, Ronald P. van Rij, Laura Vangeel, Finny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andrea Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
bioRxiv 2020.10.29.339317; doi: https://doi.org/10.1101/2020.10.29.339317
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Emma Cattermole, Eugene Chernyshenko, John D. Chodera, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Fedorov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, Itai Glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J. L. Kiappes, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha A. Lee, Bruce A. Lefker, Haim Levy, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J. Overheul, David Owen, Vladimir Psenak, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Reut Puni, Victor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Warren Thompson, Susana Tomasio, Anthony Tumber, Ioannis Vakonakis, Ronald P. van Rij, Laura Vangeel, Finny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andrea Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
bioRxiv 2020.10.29.339317; doi: https://doi.org/10.1101/2020.10.29.339317
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