New Results
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Vitaliy A. Bilenko, Vitaliy A. Bilenko, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Daniel Carney, Emma Cattermole, Edcon Chang, Eugene Chernyshenko, John D. Chodera, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Fedorov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, Itai Glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Victor D. Huliak, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Jitske Jansen, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J. L. Kiappes, Serhii O. Kinakh, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha Lee, Bruce A. Lefker, Haim Levy, Ivan G. Logvinenko, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Kostiantyn P. Melnykov, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J. Overheul, David Owen, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimir Psenak, Reut Puni, Victor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Kadi Saar, Kumar Singh Saikatendu, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, Bart Smeets, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Susana Tomasio, Igor S. Tsurupa, Anthony Tumber, Ioannis Vakonakis, Ronald P. van Rij, Laura Vangeel, Finny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andrea Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
doi: https://doi.org/10.1101/2020.10.29.339317
1The COVID Moonshot Initiative
Hagit Achdout
2Israel Institution of Biological Research
Anthony Aimon
3Diamond Light Source Ltd; Research Complex at Harwell
Elad Bar-David
2Israel Institution of Biological Research
Haim Barr
4The Weizmann Institute of Science
Amir Ben-Shmuel
2Israel Institution of Biological Research
James Bennett
5University of Oxford
Vitaliy A. Bilenko
6Enamine Ltd
Vitaliy A. Bilenko
6Enamine Ltd
Melissa L. Boby
7Memorial Sloan Kettering Cancer Center;Weil Cornell Medical College
Bruce Borden
8Folding@home Consortium
Gregory R. Bowman
9Washington University School of Medicine
Juliane Brun
5University of Oxford
Sarma BVNBS
10Sai Life Sciences
Mark Calmiano
11UCB
Anna Carbery
12University of Oxford;Diamond Light Source
Daniel Carney
13Takeda California Inc
Emma Cattermole
5University of Oxford
Edcon Chang
13Takeda California Inc
Eugene Chernyshenko
6Enamine Ltd
John D. Chodera
14Memorial Sloan Kettering Cancer Center
Austin Clyde
15Argonne National Laboratory
Joseph E. Coffland
16N/A
Galit Cohen
4The Weizmann Institute of Science
Jason Cole
17Cambridge Crystallographic Datacentre
Alessandro Contini
18University of Milan
Lisa Cox
19Life Compass Consulting Ltd
Milan Cvitkovic
20PostEra Inc.
Alex Dias
3Diamond Light Source Ltd; Research Complex at Harwell
Kim Donckers
21Katholieke Universiteit Leuven
David L. Dotson
16N/A
Alice Douangamath
3Diamond Light Source Ltd; Research Complex at Harwell
Shirly Duberstein
4The Weizmann Institute of Science
Tim Dudgeon
22Informatics Matters
Louise Dunnett
3Diamond Light Source Ltd; Research Complex at Harwell
Peter K. Eastman
23Department of Bioengineering until Sept. 1, then Department of Chemistry
Noam Erez
2Israel Institution of Biological Research
Charles J. Eyermann
24Northeastern University
Mike Fairhead
5University of Oxford
Gwen Fate
25Thames Pharma Partners
Daren Fearon
3Diamond Light Source Ltd; Research Complex at Harwell
Oleg Fedorov
5University of Oxford
Matteo Ferla
5University of Oxford
Rafaela S. Fernandes
26University of Sao Paulo
Lori Ferrins
24Northeastern University
Richard Foster
27University of Leeds
Holly Foster
27University of Leeds
Ronen Gabizon
4The Weizmann Institute of Science
Adolfo Garcia-Sastre
28Mount Sinai
Victor O. Gawriljuk
26University of Sao Paulo
Paul Gehrtz
4The Weizmann Institute of Science
Carina Gileadi
5University of Oxford
Charline Giroud
5University of Oxford
William G. Glass
14Memorial Sloan Kettering Cancer Center
Robert Glen
29University of Cambridge
Itai Glinert
2Israel Institution of Biological Research
Andre S. Godoy
26University of Sao Paulo
Marian Gorichko
30Taras Shevchenko National University of Kyiv
Tyler Gorrie-Stone
3Diamond Light Source Ltd; Research Complex at Harwell
Ed J. Griffen
31MedChemica Ltd
Storm Hassell Hart
32University of Sussex
Jag Heer
11UCB
Michael Henry
14Memorial Sloan Kettering Cancer Center
Michelle Hill
5University of Oxford
Sam Horrell
3Diamond Light Source Ltd; Research Complex at Harwell
Victor D. Huliak
6Enamine Ltd
Matthew F.D. Hurley
33Temple University
Tomer Israely
2Israel Institution of Biological Research
Andrew Jajack
20PostEra Inc.
Jitske Jansen
34Radboud University Medical Center
Eric Jnoff
11UCB
Dirk Jochmans
21Katholieke Universiteit Leuven
Tobias John
5University of Oxford
Steven De Jonghe
21Katholieke Universiteit Leuven
Anastassia L. Kantsadi
5University of Oxford
Peter W. Kenny
35Independent consultant
J. L. Kiappes
5University of Oxford
Serhii O. Kinakh
6Enamine Ltd
Lizbe Koekemoer
5University of Oxford
Boris Kovar
36M2M solutions, s.r.o
Tobias Krojer
5University of Oxford
Alpha Lee
37PostEra Inc.; University of Cambridge
Bruce A. Lefker
38Thames Pharma Partners LLC
Haim Levy
2Israel Institution of Biological Research
Ivan G. Logvinenko
6Enamine Ltd
Nir London
4The Weizmann Institute of Science
Petra Lukacik
3Diamond Light Source Ltd; Research Complex at Harwell
Hannah Bruce Macdonald
14Memorial Sloan Kettering Cancer Center
Beth MacLean
5University of Oxford
Tika R. Malla
5University of Oxford
Tatiana Matviiuk
6Enamine Ltd
Willam McCorkindale
29University of Cambridge
Briana L. McGovern
28Mount Sinai
Sharon Melamed
2Israel Institution of Biological Research
Kostiantyn P. Melnykov
6Enamine Ltd
Oleg Michurin
6Enamine Ltd
Halina Mikolajek
3Diamond Light Source Ltd; Research Complex at Harwell
Bruce F. Milne
39University of Coimbra
Aaron Morris
40PostEra Inc
Garrett M. Morris
5University of Oxford
Melody Jane Morwitzer
41Department of Pathology and Microbiology
Demetri Moustakas
42Relay Therapeutics
Aline M. Nakamura
26University of Sao Paulo
Jose Brandao Neto
3Diamond Light Source Ltd; Research Complex at Harwell
Johan Neyts
21Katholieke Universiteit Leuven
Luong Nguyen
20PostEra Inc.
Gabriela D. Noske
26University of Sao Paulo
Vladas Oleinikovas
11UCB
Glaucius Oliva
26University of Sao Paulo
Gijs J. Overheul
34Radboud University Medical Center
David Owen
3Diamond Light Source Ltd; Research Complex at Harwell
Ruby Pai
20PostEra Inc.
Jin Pan
20PostEra Inc.
Nir Paran
2Israel Institution of Biological Research
Benjamin Perry
43DNDi
Maneesh Pingle
10Sai Life Sciences
Jakir Pinjari
10Sai Life Sciences
Boaz Politi
2Israel Institution of Biological Research
Ailsa Powell
3Diamond Light Source Ltd; Research Complex at Harwell
Vladimir Psenak
36M2M solutions, s.r.o
Reut Puni
2Israel Institution of Biological Research
Victor L. Rangel
44School of Pharmaceutical Sciences of Ribeirao Preto
Rambabu N. Reddi
4The Weizmann Institute of Science
St Patrick Reid
41Department of Pathology and Microbiology
Efrat Resnick
4The Weizmann Institute of Science
Emily Grace Ripka
20PostEra Inc.
Matthew C. Robinson
20PostEra Inc.
Ralph P. Robinson
38Thames Pharma Partners LLC
Jaime Rodriguez-Guerra
45Charite Universitatsmedizin Berlin
Romel Rosales
28Mount Sinai
Dominic Rufa
14Memorial Sloan Kettering Cancer Center
Kadi Saar
29University of Cambridge
Kumar Singh Saikatendu
13Takeda California Inc
Chris Schofield
5University of Oxford
Mikhail Shafeev
6Enamine Ltd
Aarif Shaikh
10Sai Life Sciences
Jiye Shi
11UCB
Khriesto Shurrush
4The Weizmann Institute of Science
Sukrit Singh
14Memorial Sloan Kettering Cancer Center
Assa Sittner
2Israel Institution of Biological Research
Rachael Skyner
3Diamond Light Source Ltd; Research Complex at Harwell
Adam Smalley
11UCB
Bart Smeets
34Radboud University Medical Center
Mihaela D. Smilova
5University of Oxford
Leonardo J. Solmesky
4The Weizmann Institute of Science
John Spencer
32University of Sussex
Claire Strain-Damerell
3Diamond Light Source Ltd; Research Complex at Harwell
Vishwanath Swamy
10Sai Life Sciences
Hadas Tamir
2Israel Institution of Biological Research
Rachael Tennant
46Lhasa Ltd. UK
Warren Thompson
3Diamond Light Source Ltd; Research Complex at Harwell
Andrew Thompson
5University of Oxford
Susana Tomasio
47Collaborative Drug Discovery
Igor S. Tsurupa
6Enamine Ltd
Anthony Tumber
5University of Oxford
Ioannis Vakonakis
5University of Oxford
Ronald P. van Rij
34Radboud University Medical Center
Laura Vangeel
21Katholieke Universiteit Leuven
Finny S. Varghese
34Radboud University Medical Center
Mariana Vaschetto
47Collaborative Drug Discovery
Einat B. Vitner
2Israel Institution of Biological Research
Vincent Voelz
33Temple University
Andrea Volkamer
45Charite Universitatsmedizin Berlin
Frank von Delft
48Diamond Light Source Ltd; University of Oxford; Research Complex at Harwell; University of Johannesburg
Annette von Delft
5University of Oxford
Martin Walsh
3Diamond Light Source Ltd; Research Complex at Harwell
Walter Ward
49Walter Ward Consultancy & Training
Charlie Weatherall
47Collaborative Drug Discovery
Shay Weiss
2Israel Institution of Biological Research
Kris M. White
28Mount Sinai
Conor Francis Wild
5University of Oxford
Matthew Wittmann
14Memorial Sloan Kettering Cancer Center
Nathan Wright
5University of Oxford
Yfat Yahalom-Ronen
2Israel Institution of Biological Research
Daniel Zaidmann
4The Weizmann Institute of Science
Hadeer Zidane
4The Weizmann Institute of Science
Nicole Zitzmann
5University of Oxford
Posted January 30, 2022.
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Vitaliy A. Bilenko, Vitaliy A. Bilenko, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Daniel Carney, Emma Cattermole, Edcon Chang, Eugene Chernyshenko, John D. Chodera, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Fedorov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, Itai Glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Victor D. Huliak, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Jitske Jansen, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J. L. Kiappes, Serhii O. Kinakh, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha Lee, Bruce A. Lefker, Haim Levy, Ivan G. Logvinenko, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Kostiantyn P. Melnykov, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J. Overheul, David Owen, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimir Psenak, Reut Puni, Victor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Kadi Saar, Kumar Singh Saikatendu, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, Bart Smeets, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Susana Tomasio, Igor S. Tsurupa, Anthony Tumber, Ioannis Vakonakis, Ronald P. van Rij, Laura Vangeel, Finny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andrea Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
bioRxiv 2020.10.29.339317; doi: https://doi.org/10.1101/2020.10.29.339317
Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics
The COVID Moonshot Consortium, Hagit Achdout, Anthony Aimon, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Vitaliy A. Bilenko, Vitaliy A. Bilenko, Melissa L. Boby, Bruce Borden, Gregory R. Bowman, Juliane Brun, Sarma BVNBS, Mark Calmiano, Anna Carbery, Daniel Carney, Emma Cattermole, Edcon Chang, Eugene Chernyshenko, John D. Chodera, Austin Clyde, Joseph E. Coffland, Galit Cohen, Jason Cole, Alessandro Contini, Lisa Cox, Milan Cvitkovic, Alex Dias, Kim Donckers, David L. Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise Dunnett, Peter K. Eastman, Noam Erez, Charles J. Eyermann, Mike Fairhead, Gwen Fate, Daren Fearon, Oleg Fedorov, Matteo Ferla, Rafaela S. Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Ronen Gabizon, Adolfo Garcia-Sastre, Victor O. Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G. Glass, Robert Glen, Itai Glinert, Andre S. Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J. Griffen, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Victor D. Huliak, Matthew F.D. Hurley, Tomer Israely, Andrew Jajack, Jitske Jansen, Eric Jnoff, Dirk Jochmans, Tobias John, Steven De Jonghe, Anastassia L. Kantsadi, Peter W. Kenny, J. L. Kiappes, Serhii O. Kinakh, Lizbe Koekemoer, Boris Kovar, Tobias Krojer, Alpha Lee, Bruce A. Lefker, Haim Levy, Ivan G. Logvinenko, Nir London, Petra Lukacik, Hannah Bruce Macdonald, Beth MacLean, Tika R. Malla, Tatiana Matviiuk, Willam McCorkindale, Briana L. McGovern, Sharon Melamed, Kostiantyn P. Melnykov, Oleg Michurin, Halina Mikolajek, Bruce F. Milne, Aaron Morris, Garrett M. Morris, Melody Jane Morwitzer, Demetri Moustakas, Aline M. Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D. Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J. Overheul, David Owen, Ruby Pai, Jin Pan, Nir Paran, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimir Psenak, Reut Puni, Victor L. Rangel, Rambabu N. Reddi, St Patrick Reid, Efrat Resnick, Emily Grace Ripka, Matthew C. Robinson, Ralph P. Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic Rufa, Kadi Saar, Kumar Singh Saikatendu, Chris Schofield, Mikhail Shafeev, Aarif Shaikh, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Rachael Skyner, Adam Smalley, Bart Smeets, Mihaela D. Smilova, Leonardo J. Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Rachael Tennant, Warren Thompson, Andrew Thompson, Susana Tomasio, Igor S. Tsurupa, Anthony Tumber, Ioannis Vakonakis, Ronald P. van Rij, Laura Vangeel, Finny S. Varghese, Mariana Vaschetto, Einat B. Vitner, Vincent Voelz, Andrea Volkamer, Frank von Delft, Annette von Delft, Martin Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M. White, Conor Francis Wild, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Daniel Zaidmann, Hadeer Zidane, Nicole Zitzmann
bioRxiv 2020.10.29.339317; doi: https://doi.org/10.1101/2020.10.29.339317
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