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Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Ali Etemadi, Seong J An, Andrew Favor, Devon Ehnes, Zhe Li, Florian Praetorius, Max Gordon, Wei Yang, Brian Coventry, Derrick R. Hicks, Longxing Cao, Neville Bethel, Piper Heine, Analisa Murray, Stacey Gerben, Lauren Carter, Marcos Miranda, Babak Negahdari, Sangwon Lee, Cole Trapnell, Lance Stewart, Damian C. Ekiert, Joseph Schlessinger, Jay Shendure, Gira Bhabha, View ORCID ProfileHannele Ruohola-Baker, David Baker
doi: https://doi.org/10.1101/2023.03.14.532666
Natasha I Edman
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
3Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
4Medical Scientist Training Program, University of Washington,Seattle, WA 98195, USA
Rachel L Redler
5Department of Cell Biology, New York University School of Medicine, New York, NY, USA
Ashish Phal
6Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
7Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Thomas Schlichthaerle
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Sanjay R Srivatsan
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
4Medical Scientist Training Program, University of Washington,Seattle, WA 98195, USA
8Department of Genome Sciences, University of Washington, Seattle, WA, USA
Ali Etemadi
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
9Medical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Seong J An
10Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Andrew Favor
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Devon Ehnes
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
6Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
Zhe Li
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Florian Praetorius
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Max Gordon
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
6Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
Wei Yang
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Brian Coventry
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Derrick R. Hicks
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Longxing Cao
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Neville Bethel
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
11Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Piper Heine
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Analisa Murray
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Stacey Gerben
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Lauren Carter
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Marcos Miranda
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Babak Negahdari
9Medical Biotechnology Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
Sangwon Lee
10Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Cole Trapnell
8Department of Genome Sciences, University of Washington, Seattle, WA, USA
12Brotman Baty Institute for Precision Medicine, Seattle, WA, USA
13Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA
Lance Stewart
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
Damian C. Ekiert
5Department of Cell Biology, New York University School of Medicine, New York, NY, USA
14Department of Microbiology, New York University School of Medicine, New York, United States
Joseph Schlessinger
10Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Jay Shendure
8Department of Genome Sciences, University of Washington, Seattle, WA, USA
11Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
12Brotman Baty Institute for Precision Medicine, Seattle, WA, USA
13Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA
Gira Bhabha
5Department of Cell Biology, New York University School of Medicine, New York, NY, USA
Hannele Ruohola-Baker
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
6Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA
7Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
8Department of Genome Sciences, University of Washington, Seattle, WA, USA
David Baker
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
2Institute for Protein Design, University of Washington, Seattle, WA 98195, USA
11Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
Posted March 15, 2023.
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Ali Etemadi, Seong J An, Andrew Favor, Devon Ehnes, Zhe Li, Florian Praetorius, Max Gordon, Wei Yang, Brian Coventry, Derrick R. Hicks, Longxing Cao, Neville Bethel, Piper Heine, Analisa Murray, Stacey Gerben, Lauren Carter, Marcos Miranda, Babak Negahdari, Sangwon Lee, Cole Trapnell, Lance Stewart, Damian C. Ekiert, Joseph Schlessinger, Jay Shendure, Gira Bhabha, Hannele Ruohola-Baker, David Baker
bioRxiv 2023.03.14.532666; doi: https://doi.org/10.1101/2023.03.14.532666
Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies
Natasha I Edman, Rachel L Redler, Ashish Phal, Thomas Schlichthaerle, Sanjay R Srivatsan, Ali Etemadi, Seong J An, Andrew Favor, Devon Ehnes, Zhe Li, Florian Praetorius, Max Gordon, Wei Yang, Brian Coventry, Derrick R. Hicks, Longxing Cao, Neville Bethel, Piper Heine, Analisa Murray, Stacey Gerben, Lauren Carter, Marcos Miranda, Babak Negahdari, Sangwon Lee, Cole Trapnell, Lance Stewart, Damian C. Ekiert, Joseph Schlessinger, Jay Shendure, Gira Bhabha, Hannele Ruohola-Baker, David Baker
bioRxiv 2023.03.14.532666; doi: https://doi.org/10.1101/2023.03.14.532666
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