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May 20, 2022

Myriocin remodels sphingolipids and modulates proteostasis networks to enhance longevity
Nathaniel L Hepowit, Eric Blalock, Sangderk Lee, Jason A MacGurn, Robert C Dickson

bioRxiv 2022.05.20.492522; doi: https://doi.org/10.1101/2022.05.20.492522 New Results

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An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii
Jonathan Munera Lopez, Isadonna F. Tengganu, Jun Liu, John M. Murray, Luisa F. Arias Padilla, Ying Zhang, Laurence Florens, Ke Hu

bioRxiv 2022.05.20.492694; doi: https://doi.org/10.1101/2022.05.20.492694 New Results

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Cell survival enabled by leakage of a labile metabolic intermediate
Encarnacion Medina-Carmona, Luis I Gutierrez-Rus, Fadia Mannsour-Triedo, Matilda S Newton, Gloria Gamiz-Arco, Antonio J Mota, Pablo Reine, Juan Manuel Cuerva, Mariano Ortega-Munoz, Eduardo Andres-Leon, Jose Luis Ortega-Roldan, Burckhard Seelig, Beatriz Ibarra-Molero, Jose Sanchez-Ruiz

bioRxiv 2022.05.20.492833; doi: https://doi.org/10.1101/2022.05.20.492833 New Results

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Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Kayvon Pedram, D. Judy Shon, Gabrielle S. Tender, Natalia R. Mantuano, Jason J. Northey, Kevin J. Metcalf, Simon P. Wisnovsky, Nicholas M. Riley, Giovanni C. Forcina, Stacy A Malaker, Angel Kuo, Benson M. George, Caitlyn L. Miller, Kerriann M. Casey, Jose G. Vilches-Moure, Valerie M. Weaver, Heinz Laubli, Carolyn R. Bertozzi

bioRxiv 2022.05.20.492748; doi: https://doi.org/10.1101/2022.05.20.492748 New Results

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Epigenetic plasticity via adaptive DNA hypermethylation and clonal expansion underlie resistance to oncogenic pathway inhibition in pancreatic cancer
Laura K Godfrey, Jan Forster, Sven-Thorsten Liffers, Christopher Schroeder, Johannes Koester, Leonie Henschel, Kerstin U Ludwig, Marija Trajkovic-Arsic, Diana Behrens, Aldo Scarpa, Rita T Lawlor, Kathrin E Witzke, Barbara Sitek, Steven A Johnsen, Sven Rahmann, Bernhard Horsthemke, Michael Zeschnigk, Jens T Siveke

bioRxiv 2022.05.20.492826; doi: https://doi.org/10.1101/2022.05.20.492826 New Results

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Humanized CAR T cells targeting p95HER2
Macarena Roman, Irene Rius Ruiz, Ariadna Grinyo-Escuer, Santiago Duro-Sanchez, Marta Escorihuela, Ekkehard Moessner, Christian Klein, Joaquin Arribas

bioRxiv 2022.05.20.492812; doi: https://doi.org/10.1101/2022.05.20.492812 New Results

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Differences in Gut Microbiota Assembly Alter Its Ability to Metabolize Dietary Polysaccharides and Resist Clostridioides difficile Colonization
Matthew K Schnizlein, Alexandra K Standke, Mark J Garmo, Summer J Edwards, Vincent B Young

bioRxiv 2022.05.20.492827; doi: https://doi.org/10.1101/2022.05.20.492827 New Results

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Sphingolipid depletion inhibits bulk endocytosis while triggering selective clearance of the methionine transporter Mup1
Nathaniel L Hepowit, Bradley J Moon, Robert C Dickson, Jason A MacGurn

bioRxiv 2022.05.20.492841; doi: https://doi.org/10.1101/2022.05.20.492841 New Results

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Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers
Apratim Mukherjee, Jonathan Ron, Hooi Ting Hu, Tamako Nishimura, Kyoko Hanawa-Suetsugu, Bahareh Behkam, Nir Gov, Shiro Suetsugu, Amrinder Nain

bioRxiv 2022.05.20.492840; doi: https://doi.org/10.1101/2022.05.20.492840 New Results

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Cytoplasmic TDP-43 accumulation drives changes in C-bouton number and size in a mouse model of sporadic Amyotrophic Lateral Sclerosis
Anna Normann Bak, Svetlana Djukic, Marion Kadlecova, Thomas Hartig Braunstein, Dennis Bo Jensen, Claire Francesca Meehan

bioRxiv 2022.05.20.492885; doi: https://doi.org/10.1101/2022.05.20.492885 New Results

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May 20, 2022

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