Discovery and assessment of conserved Pax6 target genes and enhancers
P Coutinho, S Pavlou, S Bhatia, KJ Chalmers… - Genome …, 2011 - genome.cshlp.org
The characterization of transcriptional networks (TNs) is essential for understanding
complex biological phenomena such as development, disease, and evolution. In this study …
complex biological phenomena such as development, disease, and evolution. In this study …
Genome-wide discovery of Pax7 target genes during development
Pax7 plays critical roles in development of brain, spinal cord, neural crest, and skeletal
muscle. As a sequence-specific DNA-binding transcription factor, any direct functional role …
muscle. As a sequence-specific DNA-binding transcription factor, any direct functional role …
Novel PAX6 binding sites in the human genome and the role of repetitive elements in the evolution of gene regulation
YH Zhou, JB Zheng, X Gu, GF Saunders… - Genome …, 2002 - genome.cshlp.org
Pax6 is a critical transcription factor in the development of the eye, pancreas, and central
nervous system. It is composed of two DNA-binding domains, the paired domain (PD), which …
nervous system. It is composed of two DNA-binding domains, the paired domain (PD), which …
[HTML][HTML] Downstream genes of Pax6 revealed by comprehensive transcriptome profiling in the developing rat hindbrain
K Numayama-Tsuruta, Y Arai, M Takahashi… - BMC Developmental …, 2010 - Springer
Abstract Background The transcription factor Pax6 is essential for the development of the
central nervous system and it exerts its multiple functions by regulating the expression of …
central nervous system and it exerts its multiple functions by regulating the expression of …
Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes
F Santagati, JK Gerber, JH Blusch, C Kokubu… - Mammalian …, 2001 - Springer
As a first step towards the identification of cis-regulatory elements of Pax9 by means of
comparative genomics, we have analyzed genome regions encompassing the Pax9 gene in …
comparative genomics, we have analyzed genome regions encompassing the Pax9 gene in …
[HTML][HTML] Regulatory pathway analysis by high-throughput in situ hybridization
Automated in situ hybridization enables the construction of comprehensive atlases of gene
expression patterns in mammals. Such atlases can become Web-searchable digital …
expression patterns in mammals. Such atlases can become Web-searchable digital …
[HTML][HTML] Conserved elements in Pax6 intron 7 involved in (auto) regulation and alternative transcription
DA Kleinjan, A Seawright, AJ Childs… - Developmental …, 2004 - Elsevier
Pax6 is a transcription factor with an essential role in eye, central nervous system, and
pancreas development. Its expression pattern is restricted to these specific domains within …
pancreas development. Its expression pattern is restricted to these specific domains within …
[HTML][HTML] Zebrafish Pax9 encodes two proteins with distinct C-terminal transactivating domains of different potency negatively regulated by adjacent N-terminal …
S Nornes, I Mikkola, S Krauss, M Delghandi… - Journal of Biological …, 1996 - ASBMB
We describe the isolation of cDNA clones for zebrafish Pax9. Pax9 expression was initiated
at the end of the segmentation period in mesenchymal sclerotome cells on both sides of the …
at the end of the segmentation period in mesenchymal sclerotome cells on both sides of the …
[HTML][HTML] Mapping gene regulatory circuitry of Pax6 during neurogenesis
Pax6 is a highly conserved transcription factor among vertebrates and is important in various
aspects of the central nervous system development. However, the gene regulatory circuitry …
aspects of the central nervous system development. However, the gene regulatory circuitry …
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …
(HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and …