RT Journal Article
SR Electronic
T1 Syndecan-3 enhances anabolic bone formation through WNT signalling
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 846972
DO 10.1101/846972
A1 Francesca Manuela Johnson de Sousa Brito
A1 Andrew Butcher
A1 Addolorata Pisconti
A1 Blandine Poulet
A1 Amanda Prior
A1 Gemma Charlesworth
A1 Catherine Sperinck
A1 Michele Scotto di Mase
A1 George Bou-Gharios
A1 Robert Jurgen van ’t Hof
A1 Anna Daroszewska
YR 2019
UL http://biorxiv.org/content/early/2019/11/19/846972.abstract
AB Osteoporosis is the most common age-related metabolic bone disorder, which is characterised by low bone mass and deterioration in bone architecture, with a propensity to fragility fractures. The best treatment for osteoporosis relies on stimulation of osteoblasts to form new bone and restore bone structure, however anabolic therapeutics are few and their use is time-restricted. Here we report that Syndecan-3 (SDC3) increases new bone formation through enhancement of WNT signalling. Young adult Sdc3−/− mice have a low bone volume phenotype associated with reduced bone formation, increased bone marrow adipose tissue (BMAT), increased bone fragility and a blunted anabolic bone formation response to mechanical loading. The premature osteoporosis-like phenotype of Sdc3−/− mice is primarily explained by delayed osteoblast maturation and impaired osteoblast function, with contributing increased osteoclast-mediated bone resorption. Mechanistically, SDC3 enhances canonical WNT signalling in osteoblasts through stabilisation of Frizzled 1, making SDC3 an attractive target for novel anabolic drug development.