RT Journal Article
SR Electronic
T1 Theory bridging cell polarities with development of robust complex morphologies
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 328385
DO 10.1101/328385
A1 Silas Boye
A1 Steven Rønhild
A1 Ala Trusina
A1 Kim Sneppen
YR 2018
UL http://biorxiv.org/content/early/2018/05/22/328385.abstract
AB Despite continual renewal and damages, a multicellular organism is able to maintain its complex morphology. How is this stability compatible with the complexity and diversity of living forms? Looking for answers at protein level may be limiting as diverging protein sequences can result in similar morphologies. Inspired by the progressive role of apical-basal and planar cell polarity in development, we propose that stability, complexity, and diversity are emergent properties in populations of proliferating polarized cells. We support our hypothesis by a theoretical approach, developed to effectively capture both types of polar cell adhesions. When applied to specific cases of development - gastrulation and the origins of folds and tubes - our theory makes experimentally testable predictions pointing to the strength of polar adhesion, initial and boundary orientation of cell polarities, and the rate of cell proliferation to be major determinants of morphological diversity and stability.