TY - JOUR T1 - Study of human origin and migration from a novel genomic footprint derived from mitochondrial sequences JF - bioRxiv DO - 10.1101/848341 SP - 848341 AU - Aritra Mahapatra AU - Jayanta Mukherjee Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/11/20/848341.abstract N2 - The origin of modern human and their migration across the world is one of the most debated topics for the decades. There exist two different hypotheses, recent African origin and multi-regional evolution, based on the genomic studies, haplogroups, archaeological records, cultural behaviors, palaeontology studies, etc. Various studies placed the modern humans in a phylogenetic tree to depict the relationships among them. However, the conflicts between the results obtained from the molecular data and the archaeological and palaeontological reports still exist. We adopt a novel genomic features derived from the whole mitochondrial sequence, and using them phylogenetic trees are constructed providing a new insight on human migration. The results we derived from the genomic feature is more consistent with the archaeological findings based on the time of origin of different communities. We find that some Asian communities are placed at the basal point with a very high bootstrap score. This study roughly estimates the existence of the archaic human at 4-5 million years ago and presence of human in Africa at 800 kilo years ago. The basal position of the Asian communities show some close relationships between the modern Asians and the archaic humans along with the Africans. ER -