PT  - JOURNAL ARTICLE
AU  - Nicholas Kavish
AU  - Eric J. Connolly
AU  - Brian B. Boutwell
TI  - Genetic and Environmental Contributions to The Association Between Violent Victimization and Major Depressive Disorder
AID  - 10.1101/164194
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 164194
4099  - http://biorxiv.org/content/early/2018/05/25/164194.short
4100  - http://biorxiv.org/content/early/2018/05/25/164194.full
AB  - Research suggests victims of violent crime are more likely to suffer from major depressive disorder (MDD) compared to non-victims. Less research has utilized longitudinal data to evaluate the directionality of this relationship or examined the genetic and environmental contributions to this association across the life course. The current study evaluated 473 full-sibling pairs and 209 half-sibling pairs (N = 1,364) from the National Longitudinal Survey of Youth (Mage = 20.14, SD = 3.94). Cross-lagged models were used to examine the directionality of effects between violent victimization and MDD over time. Biometric liability models were used to examine genetic and environmental influences on single and chronic violent victimization and MDD. Violent victimization was associated with increases in MDD during late adolescence, but MDD was more associated with increased risk for violent victimization across young adulthood. Biometric analysis indicated that 20% and 30% of the association between MDD and single and chronic victimization, respectively, was accounted for by common genetic influences. Results from the current study suggest individuals who exhibit symptoms of MDD are at higher risk for chronic victimization rather than developing MDD as a result of victimization. Shared genetic liability accounted for between 20 to 30% of this longitudinal relationship.