RT Journal Article
SR Electronic
T1 VIP interneurons selectively enhance weak but behaviorally-relevant stimuli
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 858001
DO 10.1101/858001
A1 Daniel J. Millman
A1 Gabriel Koch Ocker
A1 Shiella Caldejon
A1 India Kato
A1 Josh D. Larkin
A1 Eric Kenji Lee
A1 Jennifer Luviano
A1 Chelsea Nayan
A1 Thuyanh V. Nguyen
A1 Kat North
A1 Sam Seid
A1 Cassandra White
A1 Jerome A. Lecoq
A1 R. Clay Reid
A1 Michael A. Buice
A1 Saskia E.J. de Vries
YR 2019
UL http://biorxiv.org/content/early/2019/11/29/858001.abstract
AB Vasoactive intestinal peptide-expressing (VIP) interneurons in cortex regulate feedback inhibition of pyramidal neurons through suppression of somatostatin-expressing (SST) interneurons and, reciprocally, SST neurons inhibit VIP neurons. Here, we show that VIP neurons in mouse primary visual cortex have complementary contrast tuning to SST neurons and respond synergistically to front-to-back visual motion and locomotion. Network modeling indicates that this VIP-SST mutual antagonism regulates the gain of cortex to achieve both sensitivity to behaviorally-relevant stimuli and network stability.