RT Journal Article
SR Electronic
T1 IRNdb: The database of immunologically relevant non-coding RNAs
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 037911
DO 10.1101/037911
A1 Elena Denisenko
A1 Daniel Ho
A1 Ousman Tamgue
A1 Mumin Ozturk
A1 Harukazu Suzuki
A1 Frank Brombacher
A1 Reto Guler
A1 Sebastian Schmeier
YR 2016
UL http://biorxiv.org/content/early/2016/01/26/037911.abstract
AB MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs) and other functional non-coding RNAs (ncRNAs) have emerged as pivotal regulators involved in multiple biological processes. Recently, ncRNA control of gene expression has been identified as a critical regulatory mechanism in the immune system. Despite the great efforts made to discover and characterize ncRNAs, the functional role for most remains unknown. To facilitate discoveries in ncRNA regulation of immune system related processes we developed the database of immunologically relevant ncRNAs (IRNdb), a database of ncRNAs, their immunologically relevant targets, associated biological pathways and experiments. We integrated mouse data on predicted and experimentally verified ncRNA-target interactions, ncRNA and gene annotations, biological pathways and processes, and experimental data in a uniform format with a user-friendly web interface. The current version of IRNdb documents 3,799 experimentally confirmed miRNA-target interactions between 265 miRNAs and 1,633 murine and human-derived immune-related targets. In addition, we recorded 22,453 lncRNA - immune target and 377 PIWI-interacting RNA - immune target interactions. IRNdb is a comprehensive searchable data repository which will be of help in uncovering the role of ncRNAs in immune system related processes.Database URL http://irndb.org