PT  - JOURNAL ARTICLE
AU  - Octavio Martínez
AU  - M. Humberto Reyes-Valdés
TI  - On an algorithmic definition for the components of the minimal cell
AID  - 10.1101/333682
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 333682
4099  - http://biorxiv.org/content/early/2018/05/30/333682.short
4100  - http://biorxiv.org/content/early/2018/05/30/333682.full
AB  - Living cells are highly complex systems comprising a multitude of elements that are engaged in the many convoluted processes observed during the cell cycle. However, not all elements and processes are essential for cell survival and reproduction under steady-state environmental conditions. To distinguish between essential from expendable cell components and thus define the ‘minimal cell’ and the corresponding ‘minimal genome’, we postulate that the synthesis of all cell elements can be represented as a finite set of binary operators, and within this framework we show that cell elements that depend on their previous existence to be synthesized are those that are essential for cell survival. An algorithm to distinguish essential cell elements is presented and demonstrated within an interactome. Data and functions implementing the algorithm are given as supporting information. We expect that this algorithmic approach will lead to the determination of the complete interactome of the minimal cell, which could then be experimentally validated. The assumptions behind this hypothesis as well as its consequences for experimental and theoretical biology are discussed.