PT  - JOURNAL ARTICLE
AU  - Daniel Sobrido-Cameán
AU  - Diego Robledo
AU  - Laura Sánchez
AU  - María Celina Rodicio
AU  - Antón Barreiro-Iglesias
TI  - Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys
AID  - 10.1101/335844
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 335844
4099  - http://biorxiv.org/content/early/2018/05/31/335844.short
4100  - http://biorxiv.org/content/early/2018/05/31/335844.full
AB  - Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin in axon regeneration at the level of individually identifiable descending neurons. Pharmacological and genetic treatments after a complete spinal cord injury showed that endogenous serotonin inhibits axonal regeneration in identifiable descending neurons through the activation of serotonin 1A receptors and a subsequent decrease in cAMP levels. RNA sequencing revealed that changes in the expression of genes that control axonal guidance could be a key factor on the serotonin effects during regeneration. This study provides new targets of interest for research in non-regenerating mammalian models of traumatic CNS injuries and extends the known roles of serotonin signalling during neuronal regeneration.