TY - JOUR T1 - Headache and type 2 diabetes association: a US national ambulatory case-control study JF - bioRxiv DO - 10.1101/336586 SP - 336586 AU - Anthony Nash, PhD AU - Alejo J Nevado Holgado, PhD AU - Simon Lovestone, PhD AU - M. Zameel Cader, PhD AU - Caleb Webber, PhD Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/06/04/336586.abstract N2 - Objective We investigate the joint observation between type 2 diabetes and headache using a case-control study of a US ambulatory dataset.Background Recent whole-population cohort studies propose that type 2 diabetes may have a protective effect against headache prevalence. With headaches ranked as a leading cause of disability, headache-associated comorbidities could help identify shared molecular mechanisms.Methods We performed a case-control study using the US National Ambulatory Medical Care Survey, 2009, on the joint observation between headache and specific comorbidities, namely type 2 diabetes, hypertension and anxiety, for all patients between 18 and 65 years of age. The odds ratio of having a headache and a comorbidity were calculated using conditional logistic regression, controlling for gender and age over a study population of 3,327,947 electronic health records in the absence of prescription medication data.Results We observed estimated odds ratio of 0.89 (95% CI: 0.83-0.95) of having a headache and a record of type 2 diabetes over the population, and 0.83 (95% CI: 2.02-2.57) and 0.89 (95% CI: 3.00-3.49) for male and female, respectively.Conclusions We find that patients with type 2 diabetes are less likely to present a recorded headache indication. Patients with hypertension are almost twice as likely of having a headache indication and patients with an anxiety disorder are almost three times as likely. Given the possibility of confounding indications and prescribed medications, additional studies are recommended. ER -