RT Journal Article
SR Electronic
T1 Challenged Immune System Improves Cognitive-Behavioral Responses in Homeostasis and Recovers Malaria-Induced Cognitive Impairment in Mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2019.12.13.874420
DO 10.1101/2019.12.13.874420
A1 Luciana Pereira de Sousa
A1 Flávia Lima Ribeiro-Gomes
A1 Roberto Farina de Almeida
A1 Tadeu Mello e Souza
A1 Guilherme Loureiro Werneck
A1 Diogo Onofre Gomes de Souza
A1 Cláudio Tadeu Daniel-Ribeiro
YR 2019
UL http://biorxiv.org/content/early/2019/12/13/2019.12.13.874420.abstract
AB The immune and nervous systems can be categorized as cognitive plastic systems for their ability to know and recognize “real world objects”, including microbes, and because of their prerogative of constant self-reorganization as they live learning experiences. After each antigenic or sensory occurrence, vertebrate organisms experience changes in the cellular connections of their immune and nervous systems altering their abilities and structures. Elements of the immune machinery are necessary for neurocognitive function, and the pattern of the immune response triggered by different stimuli may induce regulator or deregulator signals for the nervous functions. Here we show, for the first time, that the immune modulation with anti-inflammatory stimuli can positively regulate the behavior of healthy mice and mitigate the cognitive-behavioral deficits induced by a mild infection of C57BL/6 animals with Plasmodium berghei ANKA.