PT  - JOURNAL ARTICLE
AU  - Alma Andersson
AU  - Joseph Bergenstråhle
AU  - Michaela Asp
AU  - Ludvig Bergenstråhle
AU  - Aleksandra Jurek
AU  - José Fernández Navarro
AU  - Joakim Lundeberg
TI  - Spatial mapping of cell types by integration of transcriptomics data
AID  - 10.1101/2019.12.13.874495
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 2019.12.13.874495
4099  - http://biorxiv.org/content/early/2019/12/13/2019.12.13.874495.short
4100  - http://biorxiv.org/content/early/2019/12/13/2019.12.13.874495.full
AB  - Spatial transcriptomics and single cell RNA-sequencing offer complementary insights into the transcriptional expression landscape. We here present a probabilistic method that integrates data from both techniques, leveraging their respective strengths in such a way that we are able to spatially map cell types to a tissue. The method is applied to several different types of tissue where the spatial cell type topographies are successfully delineated.