PT  - JOURNAL ARTICLE
AU  - Xiujun Tian
AU  - Ran Wei
AU  - Junyan Shao
AU  - Hong Wang
AU  - Jing Li
AU  - Wei Zhou
AU  - Xuanguang Qin
AU  - Yinghui Hu
AU  - Haiwei Dou
AU  - Dongxing Guo
AU  - Jingyi Li
AU  - Dan Li
AU  - Baoping Xu
AU  - Deli Xin
TI  - The reduced prevalence of macrolide resistance in <em>Mycoplasma pneumoniae</em> clinical isolates from pediatric patients in Beijing in 2016
AID  - 10.1101/339317
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 339317
4099  - http://biorxiv.org/content/early/2018/06/07/339317.short
4100  - http://biorxiv.org/content/early/2018/06/07/339317.full
AB  - Older children especially from seven to thirteen years old are more prone to develop Mycoplasma pneumoniae (MP) infection; in winter children are more susceptible to infect with MP. In Beijing, China in 2016 the rates of macrolide resistance of MP were 69.48% (in total children), 61.59% (in outpatients) and 79.28% (in hospitalized patients), respectively. All the macrolide resistant isolates harbored A2063G or A2064G mutation in the 23S rRNA gene. Seven isolates showed a mixed infection. Susceptibility results showed that 73 isolates with the A2063G mutation demonstrated different levels resistance to erythromycin (MIC=8 to>256μg/ml), azithromycin (MIC=8 to>64μg/ml) and josamycin (MIC=2 to 8μg/ml). No cross-resistance was observed in the in the antibiotics of levofloxacin and tetracycline against MP.