RT Journal Article
SR Electronic
T1 Long-term alterations in brain and behavior after postnatal Zika virus infections in infant macaques
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 788794
DO 10.1101/788794
A1 Jessica Raper
A1 Zsofia Kovacs-Balint
A1 Maud Mavigner
A1 Sanjeev Gumber
A1 Mark W. Burke
A1 Jakob Habib
A1 Cameron Mattingly
A1 Damien Fair
A1 Eric Earl
A1 Eric Feczko
A1 Martin Styner
A1 Sherrie M. Jean
A1 Joyce K. Cohen
A1 Mehul S. Suthar
A1 Mar M. Sanchez
A1 Maria C. Alvarado
A1 Ann Chahroudi
YR 2019
UL http://biorxiv.org/content/early/2019/12/17/788794.abstract
AB Considering the impact that Zika virus (ZIKV) infection has on the fetal nervous system and given that the postnatal period is also a time of rapid brain growth, it is important to understand the potential neurobehavioral consequences of ZIKV infection during infancy. Postnatal ZIKV infection in a rhesus macaque (RM) model resulted in long-term behavioral, motor, and cognitive changes, including increased emotional reactivity, decreased social contact, loss of balance, and deficits in visual recognition memory at one year of age. Structural and functional MRI showed that ZIKV-infected infant RMs had persistent enlargement of lateral ventricles, smaller volumes and altered functional connectivity between brain areas important for socioemotional behavior, cognitive, and motor function (e.g. amygdala, hippocampus, cerebellum). Neuropathological changes corresponded with neuroimaging results and were consistent with the behavioral and memory deficits. Overall, this study demonstrates that postnatal ZIKV infection of infants in this model has long lasting neurodevelopmental consequences.