RT Journal Article
SR Electronic
T1 Reaction-Diffusion Model of PDGF-driven Recruitment in Experimental Glioblastoma
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 038471
DO 10.1101/038471
A1 Massey, Susan Christine
A1 Swanson, Kristin R.
YR 2016
UL http://biorxiv.org/content/early/2016/02/04/038471.abstract
AB Platelet-derived growth factor (PDGF) drives the formation of gliomas in an experimental animal model, which notably involves the recruitment of large numbers of glial progenitor cells. (Assanah 2006). In order to understand the underlying mechanism, particularly what factors influence the degree of recruitment, and how varied amounts of PDGF would affect the gross characteristics and overall appearance of tumors in the brain, we adapted a reaction diffusion model of glioma, which has been used for analyzing clinical data, to model the interactions at play in these experimental models.