RT Journal Article
SR Electronic
T1 Modelling the nuclear envelope of <em>HeLa</em> cells
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 344986
DO 10.1101/344986
A1 Cefa Karabağ
A1 Martin L. Jones
A1 Christopher J. Peddie
A1 Anne E. Weston
A1 Lucy M. Collinson
A1 Constantino Carlos Reyes-Aldasoro
YR 2018
UL http://biorxiv.org/content/early/2018/06/12/344986.abstract
AB This paper describes a framework for the automatic segmentation of the nuclear envelope of cancerous HeLa cells and the modelling of the volumetric shape against an ellipsoid. The framework is automatic and unsupervised and reported a Jaccard Similarity Index of 0.968 against a manual segmentation. The modelling of the surface provides a visual display of the variations, both smooth and rugged over the surface, and measurements can be extracted with the expectation that they can correlate with the biological characteristics of the cells.