RT Journal Article SR Electronic T1 Multiway Canonical Correlation Analysis of Brain Signals JF bioRxiv FD Cold Spring Harbor Laboratory SP 344960 DO 10.1101/344960 A1 Alain de Cheveigné A1 Giovanni M. Di Liberto A1 Dorothée Arzounian A1 Daniel D.E. Wong A1 Jens Hjortkjær A1 Søren Fuglsang A1 Lucas C. Parra YR 2018 UL http://biorxiv.org/content/early/2018/06/12/344960.abstract AB Brain signals recorded with electroencephalography (EEG), magnetoencephalography (MEG) and related techniques often have poor signal-to-noise ratio due to the presence of multiple competing sources and artifacts. A common remedy is to average over repeats of the same stimulus, but this is not applicable for temporally extended stimuli that are presented only once (speech, music, movies, natural sound). An alternative is to average responses over multiple subjects that were presented with the same identical stimuli, but differences in geometry of brain sources and sensors reduce the effectiveness of this solution. Multiway canonical correlation analysis (MCCA) brings a solution to this problem by allowing data from multiple subjects to be fused in such a way as to extract components common to all. This paper reviews the method, offers application examples that illustrate its effectiveness, and outlines the caveats and risks entailed by the method.