@article {Schikora-Tamarit345595, author = {Miquel {\`A}ngel Schikora-Tamarit and Lucas B. Carey}, title = {Poor codon optimality is a signal to degrade transcripts with frameshifts}, elocation-id = {345595}, year = {2018}, doi = {10.1101/345595}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.}, URL = {https://www.biorxiv.org/content/early/2018/06/13/345595}, eprint = {https://www.biorxiv.org/content/early/2018/06/13/345595.full.pdf}, journal = {bioRxiv} }