PT  - JOURNAL ARTICLE
AU  - Miquel Àngel Schikora-Tamarit
AU  - Lucas B. Carey
TI  - Poor codon optimality is a signal to degrade transcripts with frameshifts
AID  - 10.1101/345595
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 345595
4099  - http://biorxiv.org/content/early/2018/06/13/345595.short
4100  - http://biorxiv.org/content/early/2018/06/13/345595.full
AB  - Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.