RT Journal Article
SR Electronic
T1 Poor codon optimality is a signal to degrade transcripts with frameshifts
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 345595
DO 10.1101/345595
A1 Miquel Àngel Schikora-Tamarit
A1 Lucas B. Carey
YR 2018
UL http://biorxiv.org/content/early/2018/06/13/345595.abstract
AB Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.