TY - JOUR T1 - Computation of history-dependent mechanical damage of axonal fiber tracts in the brain: towards tracking sub-concussive and occupational damage to the brain JF - bioRxiv DO - 10.1101/346700 SP - 346700 AU - Jesse I. Gerber AU - Harsha T. Garimella AU - Reuben H. Kraft Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/06/14/346700.abstract N2 - Finite element models are frequently used to simulate traumatic brain injuries. However, current models are unable to capture the progressive damage caused by repeated head trauma. In this work, we propose a method for computing the history-dependent mechanical damage of axonal fiber bundle tracts in the brain. Through the introduction of multiple damage models, we provide the ability to link consecutive head impact simulations, so that potential injury to the brain can be tracked over time. In addition, internal damage variables are used to degrade the mechanical response of each axonal fiber bundle element. As a result, the stiffness of the aggregate tissue decreases as damage evolves. To counteract this degenerative process, we have also introduced a preliminary healing model that reverses the accumulated damage, based on a user-specified healing duration. Using two detailed examples, we demonstrate that damage produces a significant decrease in fiber stress, which ultimately propagates to the tissue level and produces a measurable decrease in overall stiffness. These results suggest that damage modeling has the potential to enhance current brain simulation techniques and lead to new insights, especially in the study of repetitive head injuries. ER -