RT Journal Article
SR Electronic
T1 Peripheral nerve resident macrophages are microglia-like cells with tissue-specific programming
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2019.12.19.883546
DO 10.1101/2019.12.19.883546
A1 Peter L Wang
A1 Aldrin KY Yim
A1 Kiwook Kim
A1 Denis Avey
A1 Rafael S. Czepielewski
A1 Marco Colonna
A1 Jeffrey Milbrandt
A1 Gwendalyn J Randolph
A1 The Immunological Genome Project
YR 2019
UL http://biorxiv.org/content/early/2019/12/20/2019.12.19.883546.abstract
AB Whereas microglia are recognized as fundamental players in central nervous system (CNS) development and function, much less is known about macrophages of the peripheral nervous system (PNS). Here we show that self-maintaining PNS macrophages share unique features with CNS microglia. By comparing gene expression across neural and conventional tissue-resident macrophages, we identified transcripts that were shared among neural resident macrophages as well as selectively enriched in PNS macrophages. Remarkably, PNS macrophages constitutively expressed genes previously identified to be upregulated by activated microglia during aging or neurodegeneration. Several microglial activation-associated and PNS macrophage-enriched genes were also expressed in spinal cord microglia at steady state. While PNS macrophages arose from both embryonic and hematopoietic precursors, their expression of activation-associated genes did not differ by ontogeny. Collectively, these data uncover shared and unique features between neural resident macrophages and emphasize the role of nerve environment for shaping PNS macrophage identity.