PT  - JOURNAL ARTICLE
AU  - Krisztina Krizsán
AU  - Éva Almási
AU  - Zsolt Merényi
AU  - Neha Sahu
AU  - Máté Virágh
AU  - Tamás Kószó
AU  - Stephen Mondo
AU  - Brigitta Kiss
AU  - Balázs Bálint
AU  - Ursula Kües
AU  - Kerrie Barry
AU  - Judit Cseklye
AU  - Botond Hegedűs
AU  - Bernard Henrissat
AU  - Jenifer Johnson
AU  - Anna Lipzen
AU  - Robin A. Ohm
AU  - István Nagy
AU  - Jasmyn Pangilinan
AU  - Juying Yan
AU  - Yi Xiong
AU  - Igor V. Grigoriev
AU  - David S. Hibbett
AU  - László G. Nagy
TI  - Transcriptomic atlas of mushroom development highlights an independent origin of complex multicellularity
AID  - 10.1101/349894
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 349894
4099  - http://biorxiv.org/content/early/2018/06/18/349894.short
4100  - http://biorxiv.org/content/early/2018/06/18/349894.full
AB  - We constructed a reference atlas of mushroom formation based on developmental transcriptome data of six species and comparisons of >200 whole genomes, to elucidate the core genetic program of complex multicellularity and fruiting body development in mushroom-forming fungi (Agaricomycetes). Nearly 300 conserved gene families and >70 functional groups contained developmentally regulated genes from five to six species, covering functions related to fungal cell wall (FCW) remodeling, targeted protein degradation, signal transduction, adhesion and small secreted proteins (including effector-like orphan genes). Several of these families, including F-box proteins, protein kinases and cadherin-like proteins, showed massive expansions in Agaricomycetes, with many convergently expanded in multicellular plants and/or animals too, reflecting broad genetic convergence among independently evolved complex multicellular lineages. This study provides a novel entry point to studying mushroom development and complex multicellularity in one of the largest clades of complex eukaryotic organisms.