RT Journal Article
SR Electronic
T1 Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 352054
DO 10.1101/352054
A1 Sabine Gretenkord
A1 Johanna K. Kostka
A1 Henrike Hartung
A1 Katja Watznauer
A1 David Fleck
A1 Angélica Minier-Toribio
A1 Marc Spehr
A1 Ileana L. Hanganu-Opatz
YR 2018
UL http://biorxiv.org/content/early/2018/06/20/352054.abstract
AB While the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system reaches full maturity during intrauterine life, controlling mother-offspring interactions and neonatal survival. Here, we elucidate the structural and functional principles underlying the communication between olfactory bulb (OB) and lateral entorhinal cortex (LEC) - the gatekeeper of limbic circuitry - during neonatal mouse development. Combining optogenetics, pharmacology, and electrophysiology in vivo with axonal tracing, we show that mitral cell-dependent discontinuous theta bursts in OB drive network oscillations and time the firing in LEC via axonal projections confined to upper cortical layers. Pharmacological silencing of OB activity diminishes entorhinal oscillations. Moreover, odor exposure boosts OB-entorhinal coupling at fast frequencies. Thus, early OB activity shapes the maturation of entorhinal circuits.