RT Journal Article
SR Electronic
T1 Logical design of oral glucose ingestion pattern minimizing blood glucose in humans
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 352955
DO 10.1101/352955
A1 Masashi Fujii
A1 Yohei Murakami
A1 Yasuaki Karasawa
A1 Yohei Sumitomo
A1 Suguru Fujita
A1 Masanori Koyama
A1 Shinsuke Uda
A1 Hiroyuki Kubota
A1 Hiroshi Inoue
A1 Katsumi Konishi
A1 Shigeyuki Oba
A1 Shin Ishii
A1 Shinya Kuroda
YR 2018
UL http://biorxiv.org/content/early/2018/06/21/352955.abstract
AB Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose 2 level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in 3 healthy human subjects, used the model to predict an optimal glucose ingestion pattern, and showed that the optimal ingestion pattern minimized the peak value of blood glucose level. Subjects orally ingested 3 doses of glucose by bolus or over 2 hours, and blood glucose, insulin, C-peptide and incretins were measured for 4 hours. We constructed an ordinary differential equation model that reproduced the time course data of the blood glucose and blood hormone levels. Using the model, we predicted that intermittent ingestion 30 minutes apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern decreased the peak value of blood glucose level. This approach could be applied to design optimal dietary ingestion patterns.In Brief As a forward problem, we measured blood glucose and hormones in three human subjects after oral glucose ingestion and constructed a mathematical model of blood glucose control. As an inverse problem, we used the model to predict the optimal oral glucose ingestion pattern that minimized the peak value of blood glucose level, and validated the pattern with the subjects.HighlightsModeling blood glucose concentrations predicts an intermittent ingestion pattern is optimalHuman validation shows ingestion at 30-minute intervals limits peak blood glucoseWe provide a strategy to design optimal dietary ingestion patterns