RT Journal Article SR Electronic T1 Estimating sleep parameters using an accelerometer without sleep diary JF bioRxiv FD Cold Spring Harbor Laboratory SP 257972 DO 10.1101/257972 A1 V.T. van Hees A1 S. Sabia A1 S.E. Jones A1 A.R. Wood A1 K.N. Anderson A1 M. Kivimäki A1 T.M. Frayling A1 A. I. Pack A1 M Bucan A1 M.I. Trenell A1 Diego R. Mazzotti A1 P. R. Gehrman A1 B. A. Singh-Manoux A1 M. N. Weedon YR 2018 UL http://biorxiv.org/content/early/2018/06/25/257972.abstract AB Wrist worn raw-data accelerometers are used increasingly in large scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. Detected sleep period time window (SPT-window), was compared against sleep diary in 3752 participants (range=60-82years) and polysomnography in sleep clinic patients (N=28) and in healthy good sleepers (N=22). The SPT-window derived from the algorithm was 10.9 and 2.9 minutes longer compared with sleep diary in men and women, respectively. Mean C-statistic to detect the SPT-window compared to polysomnography was 0.86 and 0.83 in clinic-based and healthy sleepers, respectively. We demonstrated the accuracy of our algorithm to detect the SPT-window. The value of this algorithm lies in studies such as UK Biobank where a sleep diary was not used.