TY - JOUR T1 - The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for human complex diseases JF - bioRxiv DO - 10.1101/2019.12.26.888313 SP - 2019.12.26.888313 AU - Fengzhe Xu AU - Yuanqing Fu AU - Ting-yu Sun AU - Zengliang Jiang AU - Zelei Miao AU - Menglei Shuai AU - Wanglong Gou AU - Chu-wen Ling AU - Jian Yang AU - Jun Wang AU - Yu-ming Chen AU - Ju-Sheng Zheng Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/12/26/2019.12.26.888313.abstract N2 - There is increasing interest about the interplay between host genetics and gut microbiome on human complex diseases, with prior evidence mainly derived from animal models. In addition, the shared and distinct microbiome features among human complex diseases remain largely unclear. We performed a microbiome genome-wide association study to identify host genetic variants associated with gut microbiome in a Chinese population with 1475 participants. We then conducted bi-directional Mendelian randomization analyses to examine the potential causal associations between gut microbiome and human complex diseases. We did not find evidence supporting the causal effect of gut microbiome on human complex diseases. In contrast, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by the host genetics, had potential causal effect on gut microbiome. Further disease-microbiome feature analysis suggested that gut microbiome features revealed novel relationship among human complex diseases. These results suggest that different human complex diseases share common and distinct gut microbiome features, which may help re-shape our understanding about the disease etiology in humans. ER -