RT Journal Article
SR Electronic
T1 Inducible colistin resistance via a disrupted plasmid-borne <em>mcr-1</em> gene in a 2008 Vietnamese <em>Shigella sonnei</em> isolate
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 039925
DO 10.1101/039925
A1 Duy Pham Thanh
A1 Ha Thanh Tuyen
A1 To Nguen Thi Nguyen
A1 Hao Chung The
A1 Ryan R. Wick
A1 Guy Thwaites
A1 Stephen Baker
A1 Kathryn E. Holt
YR 2016
UL http://biorxiv.org/content/early/2016/02/18/039925.abstract
AB The mcr-1 gene, which confers resistance against the last-resort antimicrobial colistin, was recently discovered in Enterobacteriaceae circulating in China. Through genome sequencing we identified a plasmid-associated inactive form of mcr-1 in a 2008 Vietnamese isolate of Shigella sonnei. The plasmid was conjugated into E. coli and mcr-1 was activated upon exposure to colistin, suggesting the gene has been circulating in human-restricted pathogens for some time but carries a selective fitness cost.