PT  - JOURNAL ARTICLE
AU  - Zeinab Esmaeilpour
AU  - Greg Kronberg
AU  - Lucas C Parra
AU  - Marom Bikson
TI  - Temporal interference stimulation targets deep brain regions by modulating neural oscillations
AID  - 10.1101/2019.12.25.888412
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 2019.12.25.888412
4099  - http://biorxiv.org/content/early/2019/12/27/2019.12.25.888412.short
4100  - http://biorxiv.org/content/early/2019/12/27/2019.12.25.888412.full
AB  - Temporal interference (TI) stimulation of the brain generates amplitude-modulated electric fields oscillating in the kHz range. A validated current-flow model of the human head estimates that amplitude-modulated electric fields are stronger in deep brain regions, while unmodulated electric fields are maximal at the cortical regions. The electric field threshold to modulate carbachol-induced gamma oscillations in rat hippocampal slices was determined for unmodulated 0.05-2 kHz sine waveforms, and 5 Hz amplitude-modulated waveforms with 0.1-2 kHz carrier frequencies. The neuronal effects are replicated with a computational network model to explore the underlying mechanisms. Experiment and model confirm the hypothesis that spatial selectivity of temporal interference stimulation depends on the phasic modulation of neural oscillations only in deep brain regions. This selectivity is governed by network adaption (e.g. GABAb) that is faster than the amplitude-modulation frequency. The applied current required depends on the neuronal membrane time-constant (e.g. axons) approaching the kHz carrier frequency of temporal interference stimulation.