PT - JOURNAL ARTICLE AU - William L. Dean AU - Robert D. Gray AU - Lynn DeLeeuw AU - Robert C. Monsen AU - Jonathan B. Chaires TI - Putting a New Spin of G4 Structure and Binding by Analytical Ultracentrifugation AID - 10.1101/359356 DP - 2018 Jan 01 TA - bioRxiv PG - 359356 4099 - http://biorxiv.org/content/early/2018/06/29/359356.short 4100 - http://biorxiv.org/content/early/2018/06/29/359356.full AB - Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of how it can be used to characterize G4 formation and to monitor small-molecule binding.