RT Journal Article
SR Electronic
T1 Impact of Premorbid Infection on Onset and Disease Activity of Rheumatoid Arthritis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 358853
DO 10.1101/358853
A1 Ruijun Zhang
A1 Jing Li
A1 Jiali Chen
A1 Xiaomei Chen
A1 Xue Li
A1 Chun Li
A1 Yuan Jia
A1 Yunshan Zhou
A1 Limin Ren
A1 Lijun Wu
A1 Jing He
A1 Zhanguo Li
YR 2018
UL http://biorxiv.org/content/early/2018/06/30/358853.abstract
AB Objective Infections have been implicated in rheumatoid arthritis (RA) development. However, the impact of premorbid infection on initiation and perpetuation of RA has not been well elucidated. Thus, we sought to conduct a large scale on-site survey to study whether premorbid infection may trigger RA and influence status of the disease.Methods Premorbid infectious events were collected in cohort of 902 RA patients from December 2015 to June 2016. Type of infections prior to RA onset and its possible effects on disease status were analyzed.Result Three hundred and thirty-four out of 902 patients (37.03%) experienced infections within one month preceding RA onset. The most frequent infections were respiratory (16.08%), intestinal (11.09%) and urinary tract (9.87%) infection, respectively. The infection was associated with increased disease activity. Early onset was found in patients with urinary infection. High disease activity risk was increased in patients who pre-exposure to urinary infection (OR=3.813, 95%CI=1.717-12.418) and upper respiratory infection (OR=2.475, 95%CI= 0.971-6.312).Conclusion Pre-exposure infections are associated with development of RA. Severe disease status of RA and persistent of active disease status are related to preceding infections.