RT Journal Article
SR Electronic
T1 The reported healthy ageing gene expression score: lack of association in two cohorts
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 034058
DO 10.1101/034058
A1 Luke C. Pilling
A1 Lorna W Harries
A1 Dena G Hernandez
A1 Andrew B Singleton
A1 George A. Kuchel
A1 Luigi Ferrucci
A1 David Melzer
YR 2016
UL http://biorxiv.org/content/early/2016/02/19/034058.abstract
AB Sood et al. report a multi-tissue RNA signature “predictive of human health, using only peripheral blood samples”. We tested this score in blood in two independent, larger cohorts and found no associations with age or related phenotypes, including muscle strength, interleukin-6 or mortality.