RT Journal Article
SR Electronic
T1 Bidirectional control of goal-oriented action selection by distinct prefrontal cortex circuits
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 307009
DO 10.1101/307009
A1 Rafiq Huda
A1 Grayson O. Sipe
A1 Elie Adam
A1 Vincent Breton-Provencher
A1 Gerald N. Pho
A1 Liadan M. Gunter
A1 Ian R. Wickersham
A1 Mriganka Sur
YR 2018
UL http://biorxiv.org/content/early/2018/07/03/307009.abstract
AB The immense behavioral repertoire of animals necessitates mechanisms that select and suppress specific actions depending on current goals. The prefrontal cortex (PFC) has been suggested to orchestrate these processes by biasing activity in its target structures, but how its vastly converging inputs and diverging outputs are coordinated to control goal-oriented actions remains unclear. Here we use a bilateral task in which mice select between symmetric but opposing actions to show that distinct outputs from a subdivision of the PFC, the anterior cingulate cortex (ACC), promote correct and suppress incorrect actions. Surprisingly, ACC outputs to the superior colliculus principally inhibit incorrect actions. Optogenetic analyses and a projection-based activity model make the unexpected prediction that feedback from the ACC to the visual cortex promotes correct actions, which we confirm. Our results show that anatomically non-overlapping but functionally complementary PFC outputs bidirectionally control actions, and suggest a candidate organizing principle for PFC circuits.