PT  - JOURNAL ARTICLE
AU  - Nicola Lorenzon
AU  - Maxime Gestin
AU  - Ülo Langel
TI  - Mimicry of dopamine 1 receptor signaling with Cell-Penetrating Peptides
AID  - 10.1101/2020.01.07.897470
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.07.897470
4099  - http://biorxiv.org/content/early/2020/01/07/2020.01.07.897470.short
4100  - http://biorxiv.org/content/early/2020/01/07/2020.01.07.897470.full
AB  - In this study, through the use of protein mimicry, a peptide was developed to activate the dopamine 1 receptor signaling pathway in substitution of L-DOPA. The peptide proved to be capable of efficiently ubiquitously penetrating the cell without the need for transfection agents or chiral recognition by specific pathways. Furthermore, the peptide induced the cellular response normally achieved through the activation of the receptor in cells that had not been treated with the natural ligand. The peptide could work as a candidate substitute to L-DOPA, leading the way for a peptides-based treatment for Parkinson’s disease.