RT Journal Article
SR Electronic
T1 Loading effects on the performance of needle free jet injections in different skin models
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 853481
DO 10.1101/853481
A1 Pankaj Rohilla
A1 Idera Lawal
A1 Andrew Le Blanc
A1 Veronica O’Brien
A1 Cormak Weeks
A1 Whitney Tran
A1 Yatish Rane
A1 Emil Khusnatdinov
A1 Jeremy Marston
YR 2020
UL http://biorxiv.org/content/early/2020/01/09/853481.abstract
AB Intradermal delivery of vaccines with jet injection is one of the leading alternatives to conventional delivery with hypodermic needles via the Mantoux technique. However, for a given fluid, the effects of various parameters related to injector design, as well as skin properties are still not well understood. Whilst the key design parameters are orifice diameter, jet speed, ampoule volume, and standoff distances, we must also consider applied load of the device on the skin, and axial skin tension. These parameters are all studied herein using different ex-vivo models (guinea pig, pig and human skin) and different fluid viscosities. We find that the applied load can have a significant effect on the amount of drug delivered through the skin, as well as the fluid dispersion pattern in the intradermal tissues. Regardless of skin type or fluid viscosity, we show that minimal standoff and applied loads of approximately 1 kg should be used to maximize injection efficiency when targeting intradermal tissue.