RT Journal Article
SR Electronic
T1 Neuronal dynamics of signal selective motor plan cancellation in the macaque dorsal premotor cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.08.897397
DO 10.1101/2020.01.08.897397
A1 Franco, Giarrocco
A1 Giampiero, Bardella
A1 Margherita, Giamundo
A1 Francesco, Fabbrini
A1 Emiliano, Brunamonti
A1 Pierpaolo, Pani
A1 Stefano, Ferraina
YR 2020
UL http://biorxiv.org/content/early/2020/01/09/2020.01.08.897397.abstract
AB Primates adopt various strategies to interact with the environment. Yet, no study has examined the effects of behavioral strategies with regard to how movement inhibition is implemented at the neuronal level. We modified a classical approach to study movement control (stop-task) by adding an extra signal – termed the Ignore signal – which influenced movement inhibition only under a specific strategy. We simultaneously recorded multisite neuronal activity from the dorsal premotor (PMd) cortex of macaque monkeys during a task and applied a state-space approach. As a result, we found that movement generation is characterized by neuronal dynamics that evolve between subspaces. When the movement is halted, this evolution is arrested and inverted. Conversely, when the Ignore signal is presented, inversion of the evolution is observed briefly and only when a specific behavioral strategy is adopted. Moreover, neuronal signatures during the inhibitory process were predictive of how PMd processes inhibitory signals, allowing the classification of the resulting behavioral strategy. Our data corroborate the PMd as a critical node in movement inhibition.