PT  - JOURNAL ARTICLE
AU  - Nalini V. Gorantla
AU  - Vinod G. Landge
AU  - Pramod G. Nagaraju
AU  - Lisni P. Sunny
AU  - Anjhu Nair
AU  - Siba P. Midya
AU  - Poornima Priyadarshini CG
AU  - Ekambaram Balaraman
AU  - Subashchandrabose Chinnathambi
TI  - Molecular Complexes for Effective Inhibition of Tau Aggregation
AID  - 10.1101/363572
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 363572
4099  - http://biorxiv.org/content/early/2018/07/06/363572.short
4100  - http://biorxiv.org/content/early/2018/07/06/363572.full
AB  - Tau is an axonal protein known to form abnormal aggregates and is the biomarker of Alzheimer’s disease. Metal-based therapeutics for inhibition of Tau aggregation is limited and rarely reported in the contemporary science. Here, the first example is reported of a rationally designed molecular cobalt(II)-complexes for effective inhibition of Tau and disaggregation of preformed Tau fibrils. The mechanistic studies revealed that the prevention of Tau aggregation by CBMCs is concentration-dependent and Tau seldom exhibits conformational changes. Interestingly, CBMCs play a dual role by causing disassembly of preformed aggregates as well as complete Tau inhibition. We believe that this unprecedented finding by the newly developed molecular complexes has a potential to lead to developing innovative metal-based therapeutics for Alzheimer’s disease.ADAlzheimer’s Disease;AβAmyloid β;CBMCsCobalt-Based Metal Complexes;NFTsNeurofibrillary Tangles;MTsMicrotubules;PHFsPaired Helical Filaments;APPAmyloid Precursor Protein