RT Journal Article
SR Electronic
T1 Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 365247
DO 10.1101/365247
A1 Katrin Strassburger
A1 Evangeline Kang
A1 Aurelio A. Teleman
YR 2018
UL http://biorxiv.org/content/early/2018/07/09/365247.abstract
AB Summary Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8.